SLK/STK10-IN-1
Based on 4 publication(s) in Google Scholar
SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 264210-49-3
- Formula: C17H13ClN2O3
- Molecular Weight:328.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SLK/STK10-IN-1
More
Biological Activity
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STK10 6.4 nM (IC50) |
SLK 7.8 nM (IC50) |
GSK-3α 14 nM (IC50) |
GSK-3β 14 nM (IC50) |
CLK2 39 nM (IC50) |
SLK/STK10-IN-1 (Cpd31, 5 μM, 4 h) inhibits the activation of ERM proteins, results in changes in cell morphology, such as cell elongation, and defective cell contraction[2].
SLK/STK10-IN-1 (Compound 31) inhibits SLK, STK10, CLK2, GSK3α and GSK3β with IC50s of 7.8, 6.4, 39, 14 and 14 nM, respectively[3].
SLK/STK10-IN-1 (Compound 31, 0-10 μM, 48 h) inhibits the migration of cell CAL51, and reduces the level of p-moesin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 264210-49-3
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Appearance Solid
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Molecular Weight 328.75
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Formula C17H13ClN2O3
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Color White to yellow
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SMILES
O=C(C(NC1=CC=CC(Cl)=C1)=C2C3=CC=CC=C3OC)NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
2026 Mar;13(16):e13310. PMID: 41589654 -
Sci Adv
Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility. [Abstract]2024 Sep 6;10(36):eadn6858. PMID: 39241071 -
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Solvent & Solubility
DMSO : 100 mg/mL (304.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.60 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Serafim RAM, et al. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64(18):13259-13278. [Content Brief]
[2]. Marshall-Burghardt S, et al., Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility. Sci Adv. 2024 Sep 6;10(36):eadn6858. [Content Brief]
[3]. Serafim RAM, et al., Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. J Med Chem. 2021 Sep 23;64(18):13259-13278. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0418 mL | 15.2091 mL | 30.4183 mL | 76.0456 mL |
| 5 mM | 0.6084 mL | 3.0418 mL | 6.0837 mL | 15.2091 mL | |
| 10 mM | 0.3042 mL | 1.5209 mL | 3.0418 mL | 7.6046 mL | |
| 15 mM | 0.2028 mL | 1.0139 mL | 2.0279 mL | 5.0697 mL | |
| 20 mM | 0.1521 mL | 0.7605 mL | 1.5209 mL | 3.8023 mL | |
| 25 mM | 0.1217 mL | 0.6084 mL | 1.2167 mL | 3.0418 mL | |
| 30 mM | 0.1014 mL | 0.5070 mL | 1.0139 mL | 2.5349 mL | |
| 40 mM | 0.0760 mL | 0.3802 mL | 0.7605 mL | 1.9011 mL | |
| 50 mM | 0.0608 mL | 0.3042 mL | 0.6084 mL | 1.5209 mL | |
| 60 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2674 mL | |
| 80 mM | 0.0380 mL | 0.1901 mL | 0.3802 mL | 0.9506 mL | |
| 100 mM | 0.0304 mL | 0.1521 mL | 0.3042 mL | 0.7605 mL |
SLK/STK10-IN-1 Related Classifications
HY-132868 Related Classifications
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