93 Results for "

Fc+receptor

" in MedChemExpress (MCE) Product Catalog:
Products (93)

93 Results for "Fc+receptor" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-109010
CAS No.: 1353552-97-2
Purity:  98.08%
Synonyms: HM71224; LY3337641
Research Areas:  

Metabolic Disease

Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis .
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2
2 Cited Publications
Cat. No.: HY-P70178
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuReceptor-Type Tyrosine-Protein Kinase FLT3/FLT3, Fc; Receptor-Type Tyrosine-Protein Kinase FLT3; FL Cytokine Receptor; Fetal Liver Kinase-2; FLK-2; Fms-Like Tyrosine Kinase 3; FLT-3; Stem Cell Tyrosine Kinase 1; STK-1; CD135; FLT3; FLK2; STK1
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1
1 Cited Publications
Cat. No.: HY-P9979
CAS No.: 1584645-37-3
Synonyms: UCB7665

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases .
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1
1 Cited Publications
Cat. No.: HY-P99222
CAS No.: 876387-05-2
Synonyms: MGA-031; PRV-031

Target:  

CD3

Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes .
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1
1 Cited Publications
Cat. No.: HY-P70601
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IgG receptor FcRn; Neonatal Fc receptor; FCRN
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1
1 Cited Publications
Cat. No.: HY-P70705
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
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Cat. No.: HY-147305
CAS No.: 1821402-21-4
Synonyms: ARGX-113
Efgartigimod alfa (ARGX-113) is a reversibility, humanized Fc receptor antagonist . Efgartigimod alfa is a anti FcRn monoclonal immunoglobulin G (IgG1) Fc fragment. Efgartigimod reduces serum levels of total IgG, including pathogenic autoantibodies, by blocking FcRn function without permanent impairment. Efgartigimod alfa can be used for generalised myasthenia gravis (gMG) and primary immune thrombocytopenia research .
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Cat. No.: HY-P991155
CAS No.: 2988886-91-3
Synonyms: JNJ-79635322; JNJ-5322

Target:  

CD3 TNF Receptor

Research Areas:  

Cancer

Ramantamig (JNJ-79635322) is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (BCMA). Ramantamig binds to BCMA and GPRC5D on multiple myeloma cells, binds to CD3ε on T cells, forms immunological synapses, and enables T-cell-mediated cytotoxicity. Ramantamig activates T cells concomitantly with inducing myeloma cell cytotoxicity, with no nonspecific T-cell activation in the absence of target myeloma cells. Ramantamig carries mutations to reduce interaction with Fc receptors and disrupt protein A binding of monomeric and homodimerized chains. Ramantamig can be used for the research of multiple myeloma .
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Cat. No.: HY-P99332
CAS No.: 219716-33-3
Synonyms: Anti-Human CD3E Recombinant Antibody; HuM291

Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .
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Cat. No.: HY-P99489
CAS No.: 2098225-93-3
Synonyms: ABBV 181; PR 1648817

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Budigalimab (ABBV 181; PR 1648817) is a humanized, recombinant IgG1 monoclonal antibody targeting programmed cell death 1 (PD-1) receptor. Budigalimab has an Fc mutation that reduces the inhibition of Fc receptor interactions and effector factors. Budigalimab can block the binding of PD-1 and PD-L1, which has anti-tumor activity. Budigalimab can be used in the study of solid tumors .
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Cat. No.: HY-P990091
CAS No.: 2756228-76-7
Synonyms: SAR 445088
Riliprubart (SAR 445088) is a selective anti-C1s humanized IgG4 monoclonal antibody with mutations that enhance its binding to the neonatal Fc receptor. Riliprubart blocks activation of the classical complement pathway, prevents the formation of the C3 convertase C4b2a, and inhibits complement-mediated hemolytic activity. Riliprubart can be used in research related to classical complement-mediated diseases, cold agglutinin disease, and chronic inflammatory demyelinating polyneuropathy. For the isotype control of Riliprubart, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P991055
CAS No.: 2649379-96-2
Synonyms: RG-6234; RO-7425781

Target:  

CD3

Research Areas:  

Inflammation/Immunology

Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990291

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse CD16.2 Antibody (9E9) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD16.2. Anti-Mouse CD16.2 Antibody (9E9) reacts with mouse CD16.2, also known as FcγRIV (Fc receptor, IgG, low affinity IV). Anti-Mouse CD16.2 Antibody (9E9) inhibits cellular CD16.2 expression and signaling and blocks FcγRIV. Anti-Mouse CD16.2 Antibody (9E9) can be used for the researches of cancer, inflammation and immunology, such as CT26 tumor and lung inflammation .
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Cat. No.: HY-W078239
CAS No.: 313701-92-7
Target:  

Ephrin Receptor

Research Areas:  

Cancer

EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC50 of 10 μM .
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Cat. No.: HY-P990863

Target:  

Fc Receptor (FcR)

Research Areas:  

Infection Inflammation/Immunology

Anti-CD32/FcγRIIA Antibody (IV.3) is a kind of mouse IgG2b chimeric antibody inhibitor, targeting to human CD32/FcγRIIA. Anti-CD32/FcγRIIA Antibody (IV.3) can block Fc receptor IIA. Anti-CD32/FcγRIIA Antibody (IV.3) can be used for the researches of inflammation and infection, such as arthritis and E. coli infection .
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Cat. No.: HY-P990959
CAS No.: 2878448-12-3

Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology

Lesigercept is a recombinant fusion protein comprising an FcERI (IgE Fc receptor subunit alpha) fused to a human IgG4 Fc .
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Cat. No.: HY-145775
CAS No.: 1425051-22-4
Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

hIgG–hFc receptor-IN-1 (comp 66) is a human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein-protein interaction inhibitor, with an IC50 of 2 μM .
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Cat. No.: HY-P991632

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Rat IgG1 (P329G) kappa is a rat-derived IgG1 κ isotype control antibody. The P329G/LALA mutations in its Fc domain reduce Fc receptor binding.
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Cat. No.: HY-P990076
CAS No.: 2131168-99-3
Synonyms: APN-301; hu14.18-IL2; EMD 273063

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity .
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Cat. No.: HY-P703825
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: High affinity immunoglobulin gamma Fc receptor I; Fcgr1; FcRI; CD64; Fc receptor; IgG; high affinity I
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