876387-05-2
876387-05-2
Chemical Structure
Teplizumab
Synonym(s): MGA-031; PRV-031
- CAS No.: 876387-05-2
- Formula:N/A
- Molecular Weight:(150 kDa)
IUPAC Name: tert-butyl (4-cyano-2-methoxyphenyl)carbamate
SMILES: [Teplizumab]
Biological Activity: Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes[1][2].
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Teplizumab | 99.73% | Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes. | ||||||||||||||||||||
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References
- [1]. Kevan C Herold, et al. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Aug 15;381(7):603-613. [Content Brief]
- [2]. Frank Waldron-Lynch, et al. I Analysis of FcR non-binding anti-CD3 mAb in humanized mice identifies novel human gut tropic cells with regulatory function that are found in patients. Sci Transl Med. 2012 Jan 25;4(118):118ra12. [Content Brief]
Keywords
