EPHA4 antagonist-1

Cat. No.: HY-W078239 Purity: 95.61%: Data Sheet
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EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC₅₀ of 10 μM.

For research use only. We do not sell to patients.

EPHA4 antagonist-1 Chemical Structure

CAS No. : 313701-92-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

EPHA2

EPHA4

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	133.4 μM Compound: NB-2	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 23673219]
MT2	CC₅₀	133.46 μM Compound: A12	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	CC₅₀	333.84 μM Compound: A12	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19932616]
MT2	EC₅₀	0.69 μM Compound: A12	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]
MT2	EC₅₀	0.7 μM Compound: NB-2	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 antigen production after 4 days by ELISA Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 antigen production after 4 days by ELISA	[PMID: 23673219]
MT2	IC₅₀	28.19 μM Compound: A12	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19932616]
MT2	IC₅₀	43.24 μM Compound: A12	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of cell-cell fusion Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of cell-cell fusion	[PMID: 19932616]
MT2	IC₅₀	55.45 μM Compound: A12	Antiviral activity against HIV1 3B in human MT2 cells assessed as reduction of virus-induced cytopathogenicity Antiviral activity against HIV1 3B in human MT2 cells assessed as reduction of virus-induced cytopathogenicity	[PMID: 19932616]

Molecular Weight

231.25

Formula

C₁₃H₁₃NO₃

CAS No.

313701-92-7

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC(N2C(C)=CC=C2C)=CC=C1O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (540.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3243 mL	21.6216 mL	43.2432 mL
5 mM	0.8649 mL	4.3243 mL	8.6486 mL
10 mM	0.4324 mL	2.1622 mL	4.3243 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 95.61%

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Data Sheet (274 KB) SDS (252 KB)

COA (252 KB) HNMR (277 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Noberini R, et al. A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des. 2011 Oct;78(4):667-78. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.3243 mL	21.6216 mL	43.2432 mL	108.1081 mL
	5 mM	0.8649 mL	4.3243 mL	8.6486 mL	21.6216 mL
	10 mM	0.4324 mL	2.1622 mL	4.3243 mL	10.8108 mL
	15 mM	0.2883 mL	1.4414 mL	2.8829 mL	7.2072 mL
	20 mM	0.2162 mL	1.0811 mL	2.1622 mL	5.4054 mL
	25 mM	0.1730 mL	0.8649 mL	1.7297 mL	4.3243 mL
	30 mM	0.1441 mL	0.7207 mL	1.4414 mL	3.6036 mL
	40 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7027 mL
	50 mM	0.0865 mL	0.4324 mL	0.8649 mL	2.1622 mL
	60 mM	0.0721 mL	0.3604 mL	0.7207 mL	1.8018 mL
	80 mM	0.0541 mL	0.2703 mL	0.5405 mL	1.3514 mL
	100 mM	0.0432 mL	0.2162 mL	0.4324 mL	1.0811 mL