Search Result

Results for "

G6Pase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Autophagy (1) FOXO (1) Fungal (1) PEPCK (1) Phosphatase (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Infection (1) Metabolic Disease (4)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active Foxo1 inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .

HY-153347

JY-2 2 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

HY-125539

Roridin E	Antibiotic Phosphatase Fungal	Infection
Roridin E is a *glucose-6-phosphatase* (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	PEPCK	Others
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-W834690

G6Pase catalytic enzyme-IN-1	Phosphatase	Metabolic Disease
G6Pase catalytic enzyme-IN-1 is a competitive inhibitor of glucose-6-phosphatase catalytic enzyme. G6Pase catalytic enzyme-IN-1 has an IC₅₀ of 10 μM in pig liver microsomes. G6Pase catalytic enzyme-IN-1 can be used in studies related to type 2 diabetes .

HY-16443

S-4048	Phosphatase	Metabolic Disease
S-4048 is a **Glucose-6-phosphatase (G6Pase) inhibitor with an IC₅₀** value of 9.4 nM for rat microsomes.

HY-RS05191

G6PC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PC1 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PC1 Human Pre-designed siRNA Set A G6PC1 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125539

Roridin E	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic Phosphatase Fungal
Roridin E is a *glucose-6-phosphatase* (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	Structural Classification other families Classification of Application Fields Terpenoids Other Diseases Phenols Polyphenols Diterpenoids Plants Disease Research Fields Source Classification	PEPCK
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

G6PC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
G6PC1 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.

G6Pase

Inhibitors & Agonists

NaturalProducts

Oligonucleotides

Natural
Products