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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
Galectin
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "Galectin" in MCE Product Catalog:
20
20 Publications Verification
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model .
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14
Domaines de recherche:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a Kd value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation .
5
Target:
Domaines de recherche:
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively . Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats .
4
4 Cited Publications
Cat. No.: HY-P70535
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS9; Ecalectin; Galectin 9; Gal-9; LGALS9A; Urate Transporter/Channel Protein; Lectin, Galactoside-Binding, Soluble, 9; Galectin; Tumor Antigen HOM-HD-21; HUAT; Galectin-9
Species:
Human
Source:
HEK293
4
4 Cited Publications
Cat. No.: HY-P70309
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; Galactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced Glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, Galactoside-Binding, Soluble, 3; Galectin; Carbohydrate-Bin
Species:
Human
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P72637
Pureté: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: LGALS9; Ecalectin; Galectin 9; Gal-9; LGALS9A; Urate Transporter/Channel Protein; Lectin, Galactoside-Binding, Soluble, 9; Galectin; Tumor Antigen HOM-HD-21; HUAT; Galectin-9
Species:
Mouse
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P77684
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; Galactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced Glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, Galactoside-Binding, Soluble, 3; Galectin; Carbohydrate-Binding Protein 35; CBP 35; Galactose-Specific Lectin 3; CBP35; Laminin-Binding Protein; Gal-3; IgE-Binding Protein; GAL3; 35 KDa Lectin; L-31; Lectin L-29; L31; Galectin-3; Galectin 3; GALBP
Species:
Mouse
Source:
HEK293
1
Target:
Domaines de recherche:
Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis .
1
1 Cited Publications
Cat. No.: HY-P990198
Target:
Domaines de recherche:
1
1
1
1 Cited Publications
Cat. No.: HY-P700074AF
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS12; Galectin-12; Galectin 12; Testicular Secretory Protein Li 26; GRIP1; Galectin; Galectin-Related Inhibitor Of Proliferation; Gal-12; Lectin, Galactoside-Binding, Soluble, 12; GAL12
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73072
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS1; Galaptin; Galectin 1; HLBP14; Lectin, Galactoside-Binding, Soluble, 1; Gal-1; GBP; HBL; Beta-Galactoside-Binding Lectin L-14-I; HPL; Putative MAPK-Activating Protein PM12; Epididymis Secretory Sperm Binding Protein; 14 KDa Laminin-Binding Protein
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74131
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS1; Galaptin; Galectin 1; HLBP14; Lectin, Galactoside-Binding, Soluble, 1; Gal-1; GBP; HBL; Beta-Galactoside-Binding Lectin L-14-I; HPL; Putative MAPK-Activating Protein PM12; Epididymis Secretory Sperm Binding Protein; 14 KDa Laminin-Binding Protein
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P79079
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; Galactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced Glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, Galactoside-Binding, Soluble, 3; Galectin; Carbohydrate-Binding Protein 35; CBP 35; Galactose-Specific Lectin 3; CBP35; Laminin-Binding Protein; Gal-3; IgE-Binding Protein; GAL3; 35 KDa Lectin; L-31; Lectin L-29; L31; Galectin-3; Galectin 3; GALBP
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-163121
CAS No.: 1096144-06-7
Domaines de recherche:
PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease .
Synonyms: N-Acetyl-D-lactosamine
Category:
Target:
Target:
Domaines de recherche:
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG5-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: GR-MD-02
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
