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Gypenoside L

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Apoptosis (3) Autophagy (1) COX (2) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (2) ERK (1) Estrogen Receptor/ERR (2) FOXO (1) Interleukin Related (2) Keap1-Nrf2 (1) MicroRNA (1) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (2) PPAR (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Sirtuin (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (1)

By Targets:

Akt (1)

AMPK (1)

Apoptosis (3)

Autophagy (1)

COX (2)

Drug Derivative (1)

Drug Intermediate (1)

Endogenous Metabolite (2)

ERK (1)

Estrogen Receptor/ERR (2)

FOXO (1)

Interleukin Related (2)

Keap1-Nrf2 (1)

MicroRNA (1)

NF-κB (3)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

PPAR (2)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (3)

Sirtuin (2)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (6)

Inflammation/Immunology (6)

Metabolic Disease (4)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1990

Gypenoside XLIX 2 Publications Verification	PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K_a value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .

HY-N8211

Gypenoside L 4 Publications Verification	p38 MAPK ERK NF-κB	Inflammation/Immunology Cancer
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

HY-N2440

Gypenoside A 1 Publications Verification	Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .

HY-N0167

Gynostemma Extract 1 Publications Verification Ginsenoside C-Mx1; Gypenoside IX	p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase	Metabolic Disease Inflammation/Immunology
Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .

HY-N0553

Gypenoside XVII 3 Publications Verification Gynosaponin S	Estrogen Receptor/ERR Endogenous Metabolite	Cardiovascular Disease
Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.

HY-N8207

Gypenoside LI 1 Publications Verification	Apoptosis MicroRNA	Cancer
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-N6881

Gypenoside XIII 1 Publications Verification	Others	Cardiovascular Disease
Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis .

HY-N7678

Gypenoside LXXV 1 Publications Verification	Others	Cancer
Gypenoside LXXV, isolated from Gynostemma pentaphyllum, is one of the deglycosylated shapes of ginsenoside Rb1. Gypenoside LXXV significantly reduces cancer cell viability and displays an anti-cancer effect .

HY-N6252

Gypenoside XLVI 1 Publications Verification	Others	Cancer
Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .

HY-N0553R

Gypenoside XVII (Standard) Gynosaponin S (Standard)	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite	Cardiovascular Disease
Gypenoside XVII (Standard) is the analytical standard of Gypenoside XVII. This product is intended for research and analytical applications. Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.

HY-N1990R

Gypenoside XLIX (Standard)	Reference Standards PPAR	Cardiovascular Disease Inflammation/Immunology
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-W027751R

2-Methylanisole (Standard)	Drug Intermediate Reference Standards	Others
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-N17992

Gypenoside UL5	Others	Metabolic Disease Inflammation/Immunology
Gypenoside UL5 (Compound UL5) is a dammarane-type triterpene saponin found in Gynostemma pentaphyllum. Gypenoside UL5 shows liver injury-inhibiting, anti-inflammatory and antioxidant properties. Gypenoside UL5 can be used for the research of hepatitis, fatty liver, and liver fibrosis .

HY-N17207

*21-keto-Gypenoside* A**	Drug Derivative	Others
21-keto-Gypenoside A is a natural triterpene.

HY-N17991

Gypenoside XCI		Others
Gypenoside XCI is a glycoside found in Gynostemma pentaphyllum .

HY-N18048

Gypenoside CII	Sirtuin	Others
Gypenoside CII is a dammarane-type triterpene saponin that can be isolated from Gynostemma pentaphyllum. Gypenoside CII exerts no significant activating effect on recombinant human Sirt1, while its congeners are potent Sirt1 agonists .

HY-N18005

Gypenoside LXIX	Others	Others
Gypenoside LXIX (Compound 4) is a glycoside found in the aerial parts of Gynostemma pentaphyllum .

Gypenoside XLIX 2 Publications Verification	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K_a value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .

Gypenoside L 4 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK ERK NF-κB
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

Gypenoside A 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis
Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .

Gynostemma Extract 1 Publications Verification Ginsenoside C-Mx1; Gypenoside IX	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification Cancer	p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase
Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .

Gypenoside XVII 3 Publications Verification Gynosaponin S	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	Estrogen Receptor/ERR Endogenous Metabolite
Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.

Gypenoside LI 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification Cancer	Apoptosis MicroRNA
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

Gypenoside XIII 1 Publications Verification	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Others
Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis .

Gypenoside LXXV 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Araliaceae Source Classification Cancer	Others
Gypenoside LXXV, isolated from Gynostemma pentaphyllum, is one of the deglycosylated shapes of ginsenoside Rb1. Gypenoside LXXV significantly reduces cancer cell viability and displays an anti-cancer effect .

Gypenoside XLVI 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer Source Classification	Others
Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .

Gypenoside XVII (Standard) Gynosaponin S (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
Gypenoside XVII (Standard) is the analytical standard of Gypenoside XVII. This product is intended for research and analytical applications. Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.

Gypenoside XLIX (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Reference Standards PPAR
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

Gypenoside UL5	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Others
Gypenoside UL5 (Compound UL5) is a dammarane-type triterpene saponin found in Gynostemma pentaphyllum. Gypenoside UL5 shows liver injury-inhibiting, anti-inflammatory and antioxidant properties. Gypenoside UL5 can be used for the research of hepatitis, fatty liver, and liver fibrosis .

*21-keto-Gypenoside* A**	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Drug Derivative
21-keto-Gypenoside A is a natural triterpene.

Gypenoside XCI	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Source Classification
Gypenoside XCI is a glycoside found in Gynostemma pentaphyllum .

Gypenoside CII	Structural Classification Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Steroids Source Classification	Sirtuin
Gypenoside CII is a dammarane-type triterpene saponin that can be isolated from Gynostemma pentaphyllum. Gypenoside CII exerts no significant activating effect on recombinant human Sirt1, while its congeners are potent Sirt1 agonists .

Gypenoside LXIX	Structural Classification Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Steroids Source Classification	Others
Gypenoside LXIX (Compound 4) is a glycoside found in the aerial parts of Gynostemma pentaphyllum .

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Natural
Products