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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
HSP90B
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "HSP90B" in MCE Product Catalog:
4
SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275 μM and 0.862 μM, respectively . SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively .
4
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
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4 Cited Publications
Cat. No.: HY-P72238
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; Heat Shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; HSP89; LAP-2; HSP90; Heat Shock Protein 90kDa Alpha Family Class A Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1; Heat
1
1 Cited Publications
Cat. No.: HY-N3417
CAS No.: 885315-96-8
Category:
Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology Croton kongensis Gagnep.
Target:
1
1 Cited Publications
Cat. No.: HY-P703226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90B1; HEL35; Prev. TRA1; Heat Shock Protein 90kDa Beta Family Member 1; Endoplasmin; Stress-Inducible Tumor Rejection Antigen Gp96; GRP94; Endothelial Cell (HBMEC) Glycoprotein; Heat Shock Protein 90 KDa Beta Member 1; Epididymis Luminal Protein 35; GP
Cat. No.: HY-RS21240
Target:
Research Areas:
Hsp90b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06419
Target:
Research Areas:
HSP90B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-170820
CAS No.: 3006788-11-7
Research Areas:
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-119732
CAS No.: 2134571-29-0
Target:
Research Areas:
KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma .
Cat. No.: HY-RS27757
Target:
Research Areas:
Hsp90b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06418
Target:
Research Areas:
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703571
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AB1; HSP84; Prev. HSPC2; Heat Shock 90kDa Protein 1, Beta; Prev. HSPCB; Heat Shock Protein 90 KDa; Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1; HSP90AB1 Protein; Heat Shock Protein Family C Member 3; HSP90-Beta; Heat Shock 90kD Prote
Species:
Source:
Cat. No.: HY-P703572
Synonyms: HSP90AB1; HSP84; Prev. HSPC2; Heat Shock 90kDa Protein 1, Beta; Prev. HSPCB; Heat Shock Protein 90 KDa; Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1; HSP90AB1 Protein; Heat Shock Protein Family C Member 3; HSP90-Beta; Heat Shock 90kD Prote
Species:
Source:
Cat. No.: HY-P85596
Synonyms: HSP90AB1; 90 kda heat shock protein beta HSP90 beta; D6S182; FLJ26984; Heat shock 84 kDa; Heat shock 90kD protein 1, beta; Heat shock 90kDa protein 1 beta; Heat shock protein 90kDa alpha; cytosolic; class B member 1; Heat shock protein beta; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-beta; HS90B_HUMAN; HSP 84; HSP 90; HSP 90 b; HSP 90B; HSP84; HSP90 BETA; HSP90ab1; HSP90B; HSPC2; HSPCB.
Cat. No.: HY-P80714
Synonyms: HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84
Cat. No.: HY-P80714A
Synonyms: HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
