17 Results for "

IgG1-type

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "IgG1-type" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99284
CAS No.: 1005389-60-5
Synonyms: MK-0646; h7C10

Target:  

IGF-1R Apoptosis

Research Areas:  

Cancer

Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [1] .
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1 Cited Publications
Cat. No.: HY-P99395
CAS No.: 1826831-79-1
Synonyms: JNJ 56022473; CSL 362

Target:  

Interleukin Related

Research Areas:  

Cancer

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models [1] .
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Cat. No.: HY-P990363
Synonyms: PTA001_A4

Target:  

Cadherin

Research Areas:  

Cancer

Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) is a CHO-expressed human-mouse chimeric antibody targeting CDH17/Cadherin-17. Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) contains an IgG1-type heavy chain and a kappa-type light chain, with a predicted molecular weight (MW) of 149.12 kDa.
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Cat. No.: HY-P99693
CAS No.: 2055006-79-4
Synonyms: GC1102

Target:  

HBV

Research Areas:  

Infection

Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection [1] .
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Cat. No.: HY-P99190
CAS No.: 946414-98-8
Synonyms: BMS-936557; MDX-1100

Target:  

CXCR

Research Areas:  

Inflammation/Immunology

Eldelumab (BMS-936557) is a human anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease [1] .
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Cat. No.: HY-P990579

Target:  

HCV

Research Areas:  

Inflammation/Immunology

Anti-CLDN6 Antibody (DS-9606A antibody) is a humanized antibody expressed in CHO cells, targeting CLDN6. Anti-CLDN6 Antibody features an IgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.84 kDa. The isotype control for Anti-CLDN6 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P99327
CAS No.: 1207446-68-1
Synonyms: BT-061

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies [1] .
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Cat. No.: HY-P99403
CAS No.: 1233953-61-1
Synonyms: GSK249320

Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease

Refanezumab (GSK249320) is a brain-penetrant IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab has the potential for the enhancement of recovery of function poststroke [1] .
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Cat. No.: HY-P99576
CAS No.: 2408661-40-3
Synonyms: OG1953

Target:  

VEGFR

Research Areas:  

Others

Tarcocimab (OG1953) is a humanized anti-VEGFA monoclonal antibody (IgG1 type). Tarcocimab is available for research in retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD).
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Cat. No.: HY-E70364
CAS No.: 1892548-76-3
Research Areas:  

Inflammation/Immunology

IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage [1].
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Cat. No.: HY-P990303

Research Areas:  

Others

Anti-Mouse 2C TCR Antibody (1B2) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse 2C TCR. Anti-Mouse 2C TCR Antibody (1B2) recognizes determinants on the variable regions of both the α and β subunits of the TCR (T cell receptor) expressed by the mouse cytotoxic T lymphocyte clone 2C. Anti-Mouse 2C TCR Antibody (1B2) can be used for the detections of immunofluorescence and flow cytometry [1].
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Cat. No.: HY-P990287

Target:  

CD1

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD1d Antibody (19G11) is a rat-derived IgG1 type antibody inhibitor, targeting to mouse CD1d. Anti-Mouse CD1d Antibody (19G11) can neutralize CD1d and inhibit the activation of invariant natural killer T (iNKT) cells. Anti-Mouse CD1d Antibody (19G11) can be used for the researches of inflammation and immunology, such as colitis [1] .
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Cat. No.: HY-145644
CAS No.: 2599039-60-6
Synonyms: C-135-LS; BMS-986414

Target:  

SARS-CoV

Research Areas:  

Infection Cancer

Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model [1].
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Cat. No.: HY-145642
CAS No.: 2640223-84-1
Synonyms: ZRC3308-A7

Target:  

SARS-CoV

Research Areas:  

Infection

Masavibart (ZRC3308-A7) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Masavibart can be used in combination with ZRC3308-B10 (HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease [1].
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Cat. No.: HY-145643
CAS No.: 2640224-48-0
Synonyms: ZRC3308-B10

Target:  

SARS-CoV

Research Areas:  

Infection

Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease [1].
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Cat. No.: HY-P990400

Research Areas:  

Inflammation/Immunology

Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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Cat. No.: HY-P990192

Target:  

MHC

Research Areas:  

Inflammation/Immunology

Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease [1].
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