Nepuvibart
Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease.
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- No. CAS: 2640224-48-0
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Human IgG1 kappa
Virus
SARS-CoV-2
Nepuvibart (ZRC3308-B10; 0-5×105 ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-A7 (ratio 1:1)[1].
Nepuvibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2AY.1 in vitro, when in combination with ZRC3308-A7 (ratio 1:1) [1].
Nepuvibart binds to the RBD of SARS-CoV-2 S1 protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
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Concentration:0-5×105 ng/mL (in combination with ZRC3308-A7)
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Incubation Time:72 h
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Result:Showed potent neutralization activity with an IC50 of 0.1283 ng/mL.
Nepuvibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)[1].
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Dosage:0.5, 2.5, 25 mg/kg
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Administration:Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
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Result:Prevented SARS-CoV-2 infection when in combination with ZRC3308-A7.
YP_009724390.1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
Chemical Information
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No. CAS 2640224-48-0
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SMILES
[Nepuvibart]
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Synonyms
ZRC3308-B10
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nepuvibart Related Classifications
HY-145643 Related Classifications
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