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Cat. No.: HY-145642

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Masavibart

(Synonyms: ZRC3308-A7)

Masavibart (ZRC3308-A7) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Masavibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Masavibart can be used in combination with ZRC3308-B10 (HY-145643) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease.

For research use only. We do not sell to patients.

CAS No.: 2640223-84-1

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (259 KB)

Masavibart Chemical Structure

CAS No.: 2640223-84-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG1 lambda

Recommend Isotype Controls

Human IgG1 lambda1, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

SARS-CoV-2

In Vitro

Masavibart (ZRC3308-A7; 0-5×10⁵ ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-B10 (ratio 1:1)^[1].
Masavibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2 AY.1 in vitro, when in combination with ZRC3308-B10 (ratio 1:1) ^[1].
Masavibart binds to the RBD of SARS-CoV-2 S1 protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model)
Concentration:

0-5×10⁵ ng/mL (in combination with ZRC3308-B10)
Incubation Time:

72 h
Result:

Showed potent neutralization activity with an IC₅₀ of 0.1527 ng/mL.

In Vivo

Masavibart (ZRC3308-A7; 0.5, 2.5, 25 mg/kg; 48 h prior to the SARS-CoV-2 infection) effectively prevents SARS-CoV-2 infection in syrian hamster, when in combination with ZRC3308-B10 (ratio 1:1)^[1].
Masavibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)^[1].
Dosage:

0.5, 2.5, 25 mg/kg
Administration:

Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection
Result:

Prevented SARS-CoV-2 infection when in combination with ZRC3308-B10.

Gene ID

43740568 [NCBI]

Accession

YP_009724390.1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 lambda

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2640223-84-1
SMILES

[Masavibart]
Synonyms

ZRC3308-A7
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Yadav PD, et al. ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 Infection. Viruses. 2021 Dec 3;13(12):2424. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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