1233953-61-1
1233953-61-1
Chemical Structure
Refanezumab
Synonym(s): GSK249320
- CAS No.: 1233953-61-1
- Formula:N/A
- Molecular Weight:(148.28 kDa)
IUPAC Name: (S)-2-((R)-tert-butylsulfinyl)-1-methyl-2,6-diazaspiro[3.3]heptane
SMILES: [Refanezumab]
Biological Activity: Refanezumab (GSK249320) is a brain-penetrant IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab has the potential for the enhancement of recovery of function poststroke[1][2].
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Refanezumab | 99.9% | Refanezumab (GSK249320) is a brain-penetrant IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab has the potential for the enhancement of recovery of function poststroke. | ||||||||||||||||||||
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References
- [1]. Diana Cash, et al. GSK249320, A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke. J Neurol Exp Neurosci. 2016;2(2):28-33. Epub 2016 Nov 21. [Content Brief]
- [2]. B Abila, et al. First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers. Clin Pharmacol Ther. 2013 Feb;93(2):163-9. [Content Brief]
Keywords
