Ogalvibart
Based on 1 Customer Validation
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model.
For research use only. We do not sell to patients.
- Purity: 95.02%
- CAS No.: 2599039-60-6
- Molecular Weight:145.06 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Virus
SARS-CoV-2
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rhesus macaques (3-11 years old)[1].
-
Dosage:10 mg/kg (in combination with 10 mg/kg C144LS)
-
Administration:75 days before infection
-
Result:Protected a subset of animals whose infectious challenge was 75 days post administration from disease.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
YP_009724390.1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 kappa
ELISA, FACS, Functional assay
-
Immobilized SARS-CoV-2 S Protein RBD (HEK293, Fc, HY-P73397) can bind Ogalvibart. The EC50 for this effect is 5.194 ng/mL.
Chemical Information
-
CAS No. 2599039-60-6
-
Appearance Liquid
-
Molecular Weight 145.06 kDa
-
Color Colorless to light yellow
-
SMILES
[Ogalvibart]
-
Synonyms
C-135-LS; BMS-986414
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (257 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)