1. Inhibitory Antibodies
  2. Tregalizumab

Tregalizumab  (Synonyms: BT-061)

Cat. No.: HY-P99327 Purity: 98.97%
COA

Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies.

For research use only. We do not sell to patients.

Tregalizumab Chemical Structure

Tregalizumab Chemical Structure

CAS No. : 1207446-68-1

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1 mg USD 430 In-stock
5 mg USD 1115 In-stock
10 mg USD 1780 In-stock
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Description

Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies[1][2][3].

IC50 & Target
In Vitro

Tregalizumab is able to activate the suppressive capacity of regulatory T cells[1].
Tregalizumab reduces proliferation and cytokine secretion when isolated PBMCs are stimulated with tetanus toxoid in a dose-dependent manner[1].
Tregalizumab (0-30 µg/mL; 18 h) treatment of PBMC induces CD4 down-modulation of T cells[2].
Tregalizumab primarily induces CD4 down-modulation at inflammatory sites[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: PBMC cells
Concentration: 0-30 µg/mL
Incubation Time: 18 h
Result: Induced CD4 down-modulation of T cells.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tregalizumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 98.97%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tregalizumab
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HY-P99327
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