Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
82 Results for "
Interleukin 2
" in MedChemExpress (MCE) Product Catalog:
Products (82)
82 Results for "Interleukin 2" in MCE Product Catalog:
5
3
Target:
Research Areas:
Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
3
3 Cited Publications
Target:
Research Areas:
PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo .
3
1
1
1 Cited Publications
Cat. No.: HY-P7037AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2
Synonyms: CHI 621
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Synonyms: Ro 24-7375
Target:
Research Areas:
Cat. No.: HY-P99479
CAS No.: 1957239-90-5
Synonyms: L19-IL2
Target:
Research Areas:
Cat. No.: HY-21293
CAS No.: 114727-43-4
Target:
Research Areas:
SU5201 is an inhibitor of interleukin-2 (IL-2) production .
Cat. No.: HY-149917
PROTAC ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. PROTAC ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo .
Cat. No.: HY-P990086
CAS No.: 2733581-99-0
Synonyms: RG-6292; RO-7296682
Target:
Research Areas:
Cat. No.: HY-177058
Target:
Research Areas:
DSP30 is a phosphorothioate cpG-oligodeoxynucleotide and a TLR9 agonist. DSP30 can activate immune system cells, including B cells and dendritic cells, by inducing proliferation and cytokine production.DSP30 can enhance the immunosuppressive function of bone marrow-multipotent mesenchymal stromal cells (BM-MSC). DSP30 combined with interleukin 2 (IL2) is an effective mitotic stimulant in B-cell disorders. DSP30 can be used for the genetic characteristic research and analysis of chronic lymphocytic leukemia (CLL) .
Cat. No.: HY-117843
CAS No.: 1245818-17-0
Research Areas:
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .
Cat. No.: HY-P991000
CAS No.: 2919583-43-8
Synonyms: AU-007; BD-8; BDG8
Target:
Research Areas:
Cat. No.: HY-16984
CAS No.: 1705602-02-3
Target:
Research Areas:
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity .
Cat. No.: HY-P3736
CAS No.: 137833-31-9
Synonyms: MP-2
Target:
Research Areas:
Cat. No.: HY-13232
CAS No.: 1149753-56-9
Target:
Research Areas:
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM .
Cat. No.: HY-108161
CAS No.: 86187-86-2
Target:
Research Areas:
LF 1695 is an immunomodulator. LF 1695 enhances the proliferative response of T cells by increasing the production of IL2 (interleukin-2) or the expression of the IL2 receptor. LF 1695 also increases CONA-induced inhibitory activity in human lymphocytes. LF 1695 can be used to study the proliferative and inhibitory activity of T cell subpopulations, as well as their role in immune regulation .
Cat. No.: HY-W066579
CAS No.: 2305-79-5
Research Areas:
4,5,6,7-Tetrahydroindazole acts as an Antimicrobial agent, an interleukin-2-induced T-cell kinase inhibitor, a positive allosteric modulator of AMPA receptors, and a ligand for CYP2E1, with a Kd1 value of 0.023 μM for its binding to rabbit-derived CYP2E1. 4,5,6,7-Tetrahydroindazole scavenges DPPH free radicals. It exhibits anti-tumor, anti-tuberculosis, and anti-inflammatory activities .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
