2305-79-5
Chemical Structure
4,5,6,7-Tetrahydroindazole
- CAS No.: 2305-79-5
- Formula:C7H10N2
- Molecular Weight:122.17
IUPAC Name: 4,5,6,7-tetrahydro-1H-indazole
InChIKey: GDSQTWDUCDSZEY-UHFFFAOYSA-N
SMILES: N1=CC2=C(N1)CCCC2
Biological Activity: 4,5,6,7-Tetrahydroindazole acts as an Antimicrobial agent, an interleukin-2-induced T-cell kinase inhibitor, a positive allosteric modulator of AMPA receptors, and a ligand for CYP2E1, with a Kd1 value of 0.023 μM for its binding to rabbit-derived CYP2E1. 4,5,6,7-Tetrahydroindazole scavenges DPPH free radicals. It exhibits anti-tumor, anti-tuberculosis, and anti-inflammatory activities[1][2].
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4,5,6,7-Tetrahydroindazole | 4,5,6,7-Tetrahydroindazole acts as an Antimicrobial agent, an interleukin-2-induced T-cell kinase inhibitor, a positive allosteric modulator of AMPA receptors, and a ligand for CYP2E1, with a Kd1 value of 0.023 μM for its binding to rabbit-derived CYP2E1. 4,5,6,7-Tetrahydroindazole scavenges DPPH free radicals. It exhibits anti-tumor, anti-tuberculosis, and anti-inflammatory activities. | |||||||||||||||||||||
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- [1]. Bala R, et al. Regioselective Synthesis of Potent 4, 5, 6, 7-Tetrahydroindazole Derivatives via Microwave-assisted Vilsmeier-Haack Reaction and their Antioxidant Activity Evaluation[J]. Letters in Organic Chemistry, 2019, 16(3): 194-201.
- [2]. Hartman JH, et al. Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes. Archives of biochemistry and biophysics. 2013 Sep 01;537(1):12-20. [Content Brief]
Keywords
