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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
KCNQ4
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "KCNQ4" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects .
Cat. No.: HY-18063
CAS No.: 1392494-64-2
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ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant .
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RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has?the?potential?for?neurologic disorders associated with neuronal hyperexcitability research .
Cat. No.: HY-RS07176
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KCNQ4 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNQ4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18392
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Kcnq4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcnq4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24873
Target:
Research Areas:
Kcnq4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnq4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-115823
CAS No.: 325457-98-5
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Research Areas:
ztz240 is a chemical modulator of voltage-gated potassium channel Kv7 (KCNQ) (KCNQ2 and 3: EC50=6.1 μM; KCNQ4: EC50=12.2 μM). ztz240 can be used in analgesia and anti-epileptic research .
Cat. No.: HY-18063A
CAS No.: 2309887-61-2
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ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant .
Cat. No.: HY-P703261
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: KCNQ4; Potassium Voltage-Gated Channel Subfamily KQT Member 4; Prev. DFNA2; Voltage-Gated Potassium Channel Subunit Kv7.4; Kv7.4; Potassium Channel KQT-Like 4; Potassium Channel, Voltage Gated KQT-Like Subfamily Q, Member 4; KQT-Like 4; Potassium Voltage-
Species:
Human
Source:
HEK293
Cat. No.: HY-182435
CAS No.: 2803111-66-0
Target:
Research Areas:
CLE-030 is a KCNQ2 agonist with non-gating-dependent current-modulating activity . CLE-030 modulates neuronal network activity. CLE-030 can be used in studies related to pain, epilepsy and benign familial neonatal convulsions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
