KCNQ4 Antibody
(Synonyms: Potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Voltage-gated potassium channel subunit Kv7.4, KCNQ4)KCNQ4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to KCNQ4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.2% BSA, 50% Glycerol and 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:5000 | 1:50-200 | 1:50-200 | 1:50-100 |
Product Details
KCNQ4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to KCNQ4.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 77kDa
Synthetic peptide of mouse KCNQ4 (aa 580-640).
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.2% BSA, 50% Glycerol and 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KCNQ4 is the pore-forming subunit of the voltage-gated potassium (Kv) channel that regulates the excitability of sensory cells in the cochlea. The KCNQ4/Kv7.4 channel consists of four pore-forming subunits assembled as tetramers, facilitating potassium ion efflux during the repolarization phase of action potentials to modulate membrane potential in excitable cells. This channel conducts slowly activating and deactivating currents, often exhibiting inward rectification at positive potentials. In vitro studies suggest selectivity for other cations beyond potassium, with affinity ranking K(+) = Rb(+) > Cs(+) > Na(+). KCNQ4 is critical for normal inner ear functions, including sound perception.
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Subcellular Localization
Basal cell membrane; Multi-pass membrane protein
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Expression
Tissue specificity: Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle. -
Isoforms & Post-Translational Modification
KCNQ4 has four isomers: P56696-1: 695 amino acids, molecular weight 77,101 Da (predicted); P56696-2: 641 amino acids, molecular weight 71,196 Da (predicted).
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Subunit
Interacts (via C-terminus) with calmodulin; forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry); the interaction is calcium-independent, constitutive, participates in the proper assembly of a functional channel. The interaction with calcium-free CALM controls channel trafficking whereas interaction with calcium-bound CALM regulates channel gating. May form a functional heteromultimeric channel with KCNQ3. Interacts with HSP90AB1; promotes cell surface expression of KCNQ4.
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SwissProt ID
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Synonyms
Potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Voltage-gated potassium channel subunit Kv7.4, KCNQ4
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