325457-89-4
325457-89-4
Chemical Structure
ICA-27243
- CAS No.: 325457-89-4
- Formula:C12H7ClF2N2O
- Molecular Weight:268.65
IUPAC Name: N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide
InChIKey: GDGUOCFTHNGPBK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(F)=C1)F)NC2=CC=C(N=C2)Cl
Biological Activity: ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ICA-27243 | 98.74% | ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-115823ztz240 -
Similarity Score 0.80
HY-101396ICA-069673 -
Similarity Score 0.78
HY-108587ICA 110381 -
Similarity Score 0.69
HY-114915PSB-1434 -
Similarity Score 0.64
HY-169055SARS-CoV-2 Mpro-IN-25 -
Similarity Score 0.63
HY-181981NTPDase/NPP1-IN-1 -
Similarity Score 0.63
HY-134753Teriflunomide impurity 3 -
Similarity Score 0.63
HY-119672Oct4 inducer-1 -
Similarity Score 0.62
HY-W011774N-(p-Chlorobenzoyl)-p-anisidine -
Explore the MedChemAI to find more analogs
References
- [1]. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. [Content Brief]
- [2]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4. [Content Brief]
