NTPDase/NPP1-IN-1
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC50 values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer.
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- CAS 番号: 2326978-03-2
- 分子式: C16H10F2N2O
- 分子量:284.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
NTPDase/NPP1-IN-1 (Compound 4d) (10 μM; 24 h) localizes specifically to the plasma membrane of human lung cancer A549 cells, and possesses stable fluorescent properties suitable for biological imaging[1].
NTPDase/NPP1-IN-1 (0-100 μM; 24-72 h) exerts time-dependent antiproliferative activity against human breast cancer cell line MCF-7, and reduces cell viability after 72 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2326978-03-2
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分子量 284.26
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分子式 C16H10F2N2O
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SMILES
O=C(C1=CC=C2N=CC=CC2=C1)NC3=C(F)C=CC=C3F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NTPDase/NPP1-IN-1 関連分類
HY-181981 関連分類
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