NTPDase/NPP1-IN-1
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC50 values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer.
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- CAS No.: 2326978-03-2
- Formule: C16H10F2N2O
- Masse moléculaire:284.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
NTPDase/NPP1-IN-1 (Compound 4d) (10 μM; 24 h) localizes specifically to the plasma membrane of human lung cancer A549 cells, and possesses stable fluorescent properties suitable for biological imaging[1].
NTPDase/NPP1-IN-1 (0-100 μM; 24-72 h) exerts time-dependent antiproliferative activity against human breast cancer cell line MCF-7, and reduces cell viability after 72 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2326978-03-2
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Masse moléculaire 284.26
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Formule C16H10F2N2O
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SMILES
O=C(C1=CC=C2N=CC=CC2=C1)NC3=C(F)C=CC=C3F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NTPDase/NPP1-IN-1 Related Classifications
HY-181981 Related Classifications
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