NTPDase/NPP1-IN-1
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC50 values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2326978-03-2
- Formula: C16H10F2N2O
- Molecular Weight:284.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NTPDase/NPP1-IN-1 (Compound 4d) (10 μM; 24 h) localizes specifically to the plasma membrane of human lung cancer A549 cells, and possesses stable fluorescent properties suitable for biological imaging[1].
NTPDase/NPP1-IN-1 (0-100 μM; 24-72 h) exerts time-dependent antiproliferative activity against human breast cancer cell line MCF-7, and reduces cell viability after 72 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2326978-03-2
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Molecular Weight 284.26
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Formula C16H10F2N2O
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SMILES
O=C(C1=CC=C2N=CC=CC2=C1)NC3=C(F)C=CC=C3F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NTPDase/NPP1-IN-1 Related Classifications
HY-181981 Related Classifications
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