NTPDase/NPP1-IN-1 

NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC₅₀ values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer^[1].

NTPDase/NPP1-IN-1 (Compound 4d) (10 μM; 24 h) localizes specifically to the plasma membrane of human lung cancer A549 cells, and possesses stable fluorescent properties suitable for biological imaging^[1].
NTPDase/NPP1-IN-1 (0-100 μM; 24-72 h) exerts time-dependent antiproliferative activity against human breast cancer cell line MCF-7, and reduces cell viability after 72 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

284.26

C₁₆H₁₀F₂N₂O

2326978-03-2

O=C(C1=CC=C2N=CC=CC2=C1)NC3=C(F)C=CC=C3F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ishaq A, et al. Quinoline carboxylic acid derivatives as potent ectonucleotidase inhibitors. Sci Rep. 2026 Feb 21.
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