KCNQ4 Protein, Human (HEK293)
KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,
Background
KCNQ4 is the pore-forming subunit of the voltage-gated potassium (Kv) channel that regulates the excitability of sensory cells in the cochlea. The KCNQ4/Kv7.4 channel consists of four pore-forming subunits assembled as tetramers, facilitating potassium ion efflux during the repolarization phase of action potentials to modulate membrane potential in excitable cells. This channel conducts slowly activating and deactivating currents, often exhibiting inward rectification at positive potentials. In vitro studies suggest selectivity for other cations beyond potassium, with affinity ranking K(+) = Rb(+) > Cs(+) > Na(+). KCNQ4 is critical for normal inner ear functions, including sound perception.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
P56696-1 (M1-D695)
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Gene ID9132
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Protein Length
Full Length of Isoform-1
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Synonyms
KCNQ4; Potassium Voltage-Gated Channel Subfamily KQT Member 4; Prev. DFNA2; Voltage-Gated Potassium Channel Subunit Kv7.4; Kv7.4; Potassium Channel KQT-Like 4; Potassium Channel, Voltage Gated KQT-Like Subfamily Q, Member 4; KQT-Like 4; Potassium Voltage-
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AA Sequence
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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Predicted Molecular Mass
77.2 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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