KCNQ4 Protein, Human (HEK293)

KCNQ4 Protein, Human (HEK293) is the recombinant human-derived KCNQ4, expressed by HEK293 , with tag Free labeled tag. ,

KCNQ4 is the pore-forming subunit of the voltage-gated potassium (Kv) channel that regulates the excitability of sensory cells in the cochlea. The KCNQ4/Kv7.4 channel consists of four pore-forming subunits assembled as tetramers, facilitating potassium ion efflux during the repolarization phase of action potentials to modulate membrane potential in excitable cells. This channel conducts slowly activating and deactivating currents, often exhibiting inward rectification at positive potentials. In vitro studies suggest selectivity for other cations beyond potassium, with affinity ranking K(+) = Rb(+) > Cs(+) > Na(+). KCNQ4 is critical for normal inner ear functions, including sound perception.

Human

HEK293

Tag Free

P56696-1 (M1-D695)

9132

Full Length of Isoform-1

MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.