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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
KMO
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "KMO" in MCE Product Catalog:
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2 Cited Publications
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GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition .
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1 Cited Publications
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UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.
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GSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC50 values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMO’s substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H2O2) production and reduces H2O2 levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimer’s disease .
Cat. No.: HY-W748591
CAS No.: 76735-57-4
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Cat. No.: HY-15500
CAS No.: 1008119-83-2
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JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor with an IC50 of 19.85 μM for mouse KMO. JM6 can be used for Alzheimer's diseases research .
Cat. No.: HY-RS07400
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KMO Human Pre-designed siRNA Set A contains three designed siRNAs for KMO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182692
CAS No.: 1953156-92-7
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KMO-IN-1 is a KMO inhibitor with a mean pIC50 of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis .
Cat. No.: HY-W748591R
CAS No.: 76735-57-4
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Cat. No.: HY-15600B
CAS No.: 1465017-87-1
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UPF-648 sodium salt is an effective inhibitor of kynurenine 3-monooxygenase (KMO), achieving approximately 81% inhibition at a concentration of 1uM, with no inhibitory effect on kynurenine aminotransferase (KAT).
Cat. No.: HY-RS18737
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Kmo Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kmo gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25224
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Kmo Rat Pre-designed siRNA Set A contains three designed siRNAs for Kmo gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P704040
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KMO; Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase); Kynurenine 3-Monooxygenase; DJ317G22.1; Kynurenine 3-Hydroxylase
Cat. No.: HY-117086
CAS No.: 1953156-61-0
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GSK065 is a KMO inhibitor with an IC50 of 2.5 nM and a Ki of 0.05 nM. GSK065 prevents the effective binding of NADPH to its substrate. GSK065 can be used in studies related to multiple organ dysfunction syndrome associated with acute pancreatitis .
Cat. No.: HY-182456
CAS No.: 1426319-74-5
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CHDI-340246 is an orally active kynurenine monooxygenase (KMO) inhibitor. CHDI-340246 blocks KMO activity, alters the metabolic flux of the kynurenine pathway, inhibits the production of 3-hydroxykynurenine and quinolinic acid, elevates the levels of kynurenine and kynurenic acid, and restores electrophysiological abnormalities in transgenic mouse models of Huntington's disease. CHDI-340246 can be used in studies related to Huntington's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
