UPF-648 sodium salt
Based on 1 publication(s) in Google Scholar
UPF-648 sodium salt is an effective inhibitor of kynurenine 3-monooxygenase (KMO), achieving approximately 81% inhibition at a concentration of 1uM, with no inhibitory effect on kynurenine aminotransferase (KAT).
For research use only. We do not sell to patients.
- CAS No.: 1465017-87-1
- Formula: C11H7Cl2NaO3
- Molecular Weight:281.07
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) UPF-648 sodium salt
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Biological Activity
Chemical Information
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CAS No. 1465017-87-1
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Molecular Weight 281.07
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Formula C11H7Cl2NaO3
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SMILES
ClC1=C(Cl)C=CC(C([C@@]2([H])C[C@]2([H])C([O-])=O)=O)=C1.[Na+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Chem Neurosci
UPF 648, a Selective KMO Inhibitor, Attenuates Psychomotor and Cognitive Impairment in Chronic Kidney Disease. [Abstract]2025 Mar 5;16(5):908-919. PMID: 39961731
Purity & Documentation
References
[1]. Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109(2):316-25. [Content Brief]
[2]. Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85(4):845-54. [Content Brief]
[3]. Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UPF-648 sodium salt Related Classifications
HY-15600B Related Classifications
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