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MS-1

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45

Inhibitors & Agonists

24

Peptides

1

Natural
Products

2

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12288
    Ozanimod
    4 Publications Verification

    RPC-1063

    		 LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod (RPC-1063) is a CNS-penetrant sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .
    Ozanimod
  • HY-12288A
    Ozanimod hydrochloride
    4 Publications Verification

    RPC-1063 hydrochloride

    		 LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) .
    Ozanimod hydrochloride
  • HY-157414
    Azide-A-DSBSO crosslinker

    		Biochemical Assay Reagents Others
    Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) [1] .
    Azide-A-DSBSO crosslinker
  • HY-109192
    Tolebrutinib
    Maximum Cited Publications
    7 Publications Verification

    SAR442168; PRN2246

    		 Btk Neurological Disease
    Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS) .
    Tolebrutinib
  • HY-P5982
    PTPσ Inhibitor, ISP

    		Phosphatase Neurological Disease
    PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .
    PTPσ Inhibitor, ISP
  • HY-158415
    ATPase-IN-4

    		ATP Synthase EHD Protein Cancer
    ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of EHD4 (IC50: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity [1]
    ATPase-IN-4
  • HY-150307
    KP-302

    		Protein Arginine Deiminase Inflammation/Immunology
    KP-302 (Compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reverses physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminates T cell infiltration in the brain. KP-302 can be studied in research as a disease-modifying agent for MS .
    KP-302
  • HY-P10532
    Myelin basic protein, MBP (68-86)

    		PKC Others Inflammation/Immunology
    Myelin basic protein, MBP (68-86) is the portion of the 68th to 86th amino acid residues in the MBP protein sequence. Myelin basic protein, MBP (68-86) can act as an autoantigen, triggering the immune system to attack its own myelin. Myelin basic protein, MBP (68-86) is used as one of the immunogens in the experimental autoimmune encephalomyelitis (EAE) animal model to study immune responses associated with multiple sclerosis (MS) .
    Myelin basic protein, MBP (68-86)
  • HY-34611
    Boc-L-2,4-Diaminobutyric acid

    N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH

    		 Drug Intermediate ASCT Neurological Disease Cancer
    Boc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS .
    Boc-L-2,4-Diaminobutyric acid
  • HY-172967
    SARM1-IN-5

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) .
    SARM1-IN-5
  • HY-E70271
    γ-Linolenoyl-CoA

    6Z,9Z,12Z-Octadecatrienoyl-coenzyme A; γ-Linolenoylcoenzyme A; 6Z,9Z,12Z-Octadecatrienoyl-CoA

    		 Endogenous Metabolite Metabolic Disease
    γ-Linolenoyl-CoA (C18:3(n6)-CoA) is a fatty acyl-CoA that can be used for lipidomics analysis of fatty acid-coenzyme A (FA-CoA) through LCMS/MS .
    γ-Linolenoyl-CoA
  • HY-128879
    VP3.15

    		Phosphodiesterase (PDE) GSK-3 Neurological Disease
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS) .
    VP3.15
  • HY-119221
    AUY954

    		LPL Receptor Neurological Disease Inflammation/Immunology
    AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis [1] .
    AUY954
  • HY-P11706
    MS1 peptide

    		Bcl-2 Family Cancer
    MS-1 peptide is a peptide for BH3 profiling. MS-1 peptide triggers higher depolarization of mitochondrial membrane in melanoma cells pre-treated with Encorafenib (HY-15605). MS1 peptide can be used for the research of BRAF V600E melanoma [1].
    MS1 peptide
  • HY-N15952
    MS 1

    		Biochemical Assay Reagents Inflammation/Immunology
    MS 1 (Momordica saponin I) is a vaccine adjuvant found in the seeds of perennial Momordica cochinchinensis Spreng [1].
    MS 1
  • HY-158725
    N-Octadecenoyl-(cis-9)-sulfatide

    		Endogenous Metabolite Others
    N-Octadecenoyl-(cis-9) -Sulfatide is a glycolipid found in the brains of mice. N-Octadecenoyl-(cis-9) -Sulfatide can be used as a standard for the determination of C18:13 '-mergogalactosyllactose in dry blood stains of patients with chromatic leukodystrophy (MLD) by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) .
    N-Octadecenoyl-(cis-9)-sulfatide
  • HY-176731
    MSK-9

    		P2X Receptor Neurological Disease
    MSK-9 is a positive allosteric modulator of the P2X4 receptor with dual activities of enhancing ion conductance and delaying receptor inactivation. MSK-9 stabilizes the open state of the P2X4 receptor through rigid 3-piperidinyl and hydrophobic menthyl substituents. MSK-9 can be used in the study of multiple sclerosis (MS) .
    MSK-9
  • HY-12288R
    Ozanimod (Standard)

    RPC-1063 (Standard)

    		 Reference Standards LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod (Standard) is the analytical standard of Ozanimod. This product is intended for research and analytical applications. Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .
    Ozanimod (Standard)
  • HY-14977
    CS-0777-P

    		LPL Receptor Inflammation/Immunology
    CS-0777-P, the phosphorylated form of CS-0777, acts as a potent and selective modulator of the S1P receptor-1 (S1P1). It exhibits approximately 320-fold higher agonist activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. In pharmacological studies, CS-0777-P demonstrated significant effects in vitro as an S1P1 and S1P3 agonist, leading to lowered peripheral blood lymphocyte counts and suppressive effects on experimental autoimmune encephalomyelitis (EAE) in rats. Pharmacokinetic studies in rats revealed rapid lymphocyte count reductions following oral administration, making CS-0777 a promising candidate currently undergoing clinical trials for the treatment of multiple sclerosis (MS) .
    CS-0777-P
  • HY-179558
    MS1-96

    		PD-1/PD-L1 Cancer
    MS1-96 is an orally active PD-L1 (programmed death-ligand 1) degrader. MS1-96 effectively reduced PD-L1 protein levels across multiple colorectal cancer (CRC) cell lines. MS1-96 directly binds to PD-L1 (KD = 2.58 μM) and enhances the interaction between HIP1R and PD-L1, thereby altering the intracellular trafficking of PD-L1 within clathrin-coated vesicles. MS1-96 induces abnormal N-glycosylation of PD-L1, destabilizing the protein and hastening its lysosome-mediated degradation. MS1-96 can be used for the study of colorectal cancer [1].
    MS1-96
  • HY-108353S
    Isoprenaline-d7 acetate

    		Isotope-Labeled Compounds Others
    Isoprenalin-d7 acetate is an internal standard for the determination of isoproterenol by GC- or LC-MS .
    Isoprenaline-d7 acetate
  • HY-155789
    C17 Globotriaosylceramide (d18:1/17:0)

    Ceramide trihexoside (d18:1/17:0); Gb3(d18:1)(C17:0)

    		 Biochemical Assay Reagents Others
    C17 Globotriaosylceramide (d18:1/17:0) is a sphygosine lipid that can be used to quantify Globotriaosylceramide in plasma and urine of patients with Fabry disease by gas chromatography-mass spectrometry (GC-MS) .
    C17 Globotriaosylceramide (d18:1/17:0)
  • HY-101266A
    Milademetan tosylate

    DS-3032 tosylate

    		 MDM-2/p53 Cancer
    Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhibitor for MDM2. Milademetan tosylate arrests the cell cycle at G1 pahse, induces the apoptosis Milademetan tosylate restores the p53 activity by targeting the p53-MDM2 interaction, and exhibits anticancer activity against Merkel cell carcinoma (MCC) [1].
    Milademetan tosylate
  • HY-P1052A
    Myelin Basic Protein(87-99) TFA

    		PKC Inflammation/Immunology
    Myelin Basic Protein(87-99) TFA is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) TFA causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS) .
    Myelin Basic Protein(87-99) TFA
  • HY-144126
    S1P1 agonist 5

    		LPL Receptor Inflammation/Immunology
    S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS) .
    S1P1 agonist 5
  • HY-130229
    (±)5,6-DHET lactone

    (±)5,6-DiHETrE lactone

    		 Drug Derivative Cardiovascular Disease
    5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
    (±)5,6-DHET lactone
  • HY-RS25604
    Abra Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Abra Rat Pre-designed siRNA Set A contains three designed siRNAs for Abra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Abra Rat Pre-designed siRNA Set A
    Abra Rat Pre-designed siRNA Set A
  • HY-P11561
    NFLINETAR

    		Biochemical Assay Reagents Others
    NFLINETAR is a peptide from egg proteins. NFLINETAR can be used as a marker peptide for the detection of egg allergens using UHPLC-MS/MS .
    NFLINETAR
  • HY-P11560
    YLLDLLPAAASHR

    		Biochemical Assay Reagents Others
    YLLDLLPAAASHR is a peptide from egg proteins. YLLDLLPAAASHR can be used as a marker peptide for the detection of egg allergens using UHPLC-MS/MS .
    YLLDLLPAAASHR
  • HY-P11563
    RPFYSNAPQEIFIQQGR

    		Biochemical Assay Reagents Others
    RPFYSNAPQEIFIQQGR is a peptide that can be isolated from peanut proteins. RPFYSNAPQEIFIQQGR can be used as a marker peptide for the detection of peanut allergens using UHPLC-MS/MS .
    RPFYSNAPQEIFIQQGR
  • HY-P11564
    FNLAGNHEQEFLR

    		Biochemical Assay Reagents Others
    FNLAGNHEQEFLR is a peptide that can be isolated from peanut proteins. FNLAGNHEQEFLR can be used as a marker peptide for the detection of peanut allergens using UHPLC-MS/MS .
    FNLAGNHEQEFLR
  • HY-P11570
    HQGLPQEVLNENLLR

    		Biochemical Assay Reagents Others
    HQGLPQEVLNENLLR is a peptide that can be isolated from milk proteins. HQGLPQEVLNENLLR can be used as a marker peptide for the detection of milk allergens using UHPLC-MS/MS .
    HQGLPQEVLNENLLR
  • HY-P11566
    ISTLNSLTLPALR

    		Biochemical Assay Reagents Others
    ISTLNSLTLPALR is a soybean peptide that can be isolated from soybean proteins. ISTLNSLTLPALR can be used as a marker peptide for the detection of soybean allergens using UHPLC-MS/MS .
    ISTLNSLTLPALR
  • HY-P11569
    LITLAIPVNKPGR

    		Biochemical Assay Reagents Others
    LITLAIPVNKPGR is a soybean peptide that can be isolated from soybean proteins. LITLAIPVNKPGR can be used as a marker peptide for the detection of soybean allergens using UHPLC-MS/MS .
    LITLAIPVNKPGR
  • HY-P11565
    TANELNLLILR

    		Biochemical Assay Reagents Others
    TANELNLLILR is a peanut peptide that can be isolated from peanut proteins. TANELNLLILR can be used as a marker peptide for the detection of peanut allergens using UHPLC-MS/MS .
    TANELNLLILR
  • HY-P11567
    EAFGVNMQIVR

    		Biochemical Assay Reagents Others
    EAFGVNMQIVR is a soybean peptide that can be isolated from soybean proteins. EAFGVNMQIVR can be used as a marker peptide for the detection of soybean allergens using UHPLC-MS/MS .
    EAFGVNMQIVR
  • HY-P11568
    ELINLATMCR

    		Biochemical Assay Reagents Others
    ELINLATMCR is a soybean peptide that can be isolated from soybean proteins. ELINLATMCR can be used as a marker peptide for the detection of soybean allergens using UHPLC-MS/MS .
    ELINLATMCR
  • HY-P11556
    LR-13

    		Biochemical Assay Reagents Others
    LR-13 is a signature peptide identified from the egg white allergen ovalbumin (OVA). LR-13 can be used as a marker peptide for the detection of OVA allergens using UHPLC-MS/MS .
    LR-13
  • HY-P11559
    NIGELGVEK

    		Biochemical Assay Reagents Others
    NIGELGVEK, derived from hen egg proteins, shows homology with peptides from Anas platyrhynchos (mallard duck) eggs. NIGELGVEK can be used as a marker peptide for the detection of egg allergens using UHPLC-MS/MS .
    NIGELGVEK
  • HY-P11558
    NIPFAEYPTYK

    		Biochemical Assay Reagents Others
    NIPFAEYPTYK, derived from hen egg proteins, shows homology with peptides from Anas platyrhynchos (mallard duck) eggs. NIPFAEYPTYK can be used as a marker peptide for the detection of egg allergens using UHPLC-MS/MS .
    NIPFAEYPTYK
  • HY-P11557
    EALQPIHDLADEAISR

    		Biochemical Assay Reagents Others
    EALQPIHDLADEAISR, derived from egg yolk proteins, is an egg peptide found in both hen eggs and Coturnix japonica eggs. EALQPIHDLADEAISR can be used as a marker peptide for the detection of egg allergens using UHPLC-MS/MS .
    EALQPIHDLADEAISR
  • HY-W653727
    BTS44596

    Prochloraz-desimidazole-formylamino

    		 Drug Metabolite Others
    BTS44596 (Prochloraz-desimidazole-formylamino) is a metabolite of the antifungal agent Prochloraz (HY-B0845). BTS44596 is one of the core target analytes for regulatory monitoring of Prochloraz residue limits in fruits and vegetables as well as for simultaneous detection via LC-MS/MS .
    BTS44596
  • HY-P11046
    IIIM1

    		Interleukin Related Inflammation/Immunology
    IIIM1 is an orally active anti-inflammatory peptide. IIIM1 ameliorates the symptoms of experimental autoimmune encephalomyelitis (EAE) by stimulating the proliferation of regulatory T cells and inducing them to produce RA1, and regulating the cytokine balance. IIIM1 can be used in the research of multiple sclerosis (MS) .
    IIIM1
  • HY-172967A
    (R)-SARM1-IN-5

    		Toll-like Receptor (TLR) Neurological Disease Inflammation/Immunology
    (R)-SARM1-IN-5 is the (R)-enantiomer of SARM1-IN-5 (HY-172967). SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) .
    (R)-SARM1-IN-5
  • HY-12288S
    Ozanimod-d6

    RPC-1063-d6

    		 Isotope-Labeled Compounds LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod-d6 (RPC-1063-d6) is the deuterium labeled Ozanimod (HY-12288). Ozanimod (RPC-1063) is a CNS-penetrant sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .
    Ozanimod-d6

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