820240-77-5
Chemical Structure
AUY954
- CAS No.: 820240-77-5
- Formula:C25H20F3NO2S
- Molecular Weight:455.49
IUPAC Name: 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid
InChIKey: SKYYWSWIUKISCX-UHFFFAOYSA-N
SMILES: O=C(CCNCC1=CC2=C(SC(C3=CC(C(F)(F)F)=C(C4=CC=CC=C4)C=C3)=C2)C=C1)O
Biological Activity: AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis[1][2].
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AUY954 | AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis. | |||||||||||||||||||||
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- [1]. Pan S,et al. A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006;13(11):1227-1234. [Content Brief]
- [2]. Zhang ZY, et al. AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis. J Neuroimmunol. 2009;216(1-2):59-65. [Content Brief]
Keywords
