2082765-42-0
2082765-42-0
Chemical Structure
KP-302
- CAS No.: 2082765-42-0
- Formula:C20H23N5O2
- Molecular Weight:365.43
InChIKey: XLISVTDEJLYVTB-KRWDZBQOSA-N
SMILES: O=C(C1=CC=CN1C)N[C@H](C(NCC2=CC=CC=C2)=O)CCN3C=CN=C3
Biological Activity: KP-302 (Compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reverses physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminates T cell infiltration in the brain. KP-302 can be studied in research as a disease-modifying agent for MS[1][2].
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KP-302 | 99.78% | KP-302 (Compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reverses physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminates T cell infiltration in the brain. KP-302 can be studied in research as a disease-modifying agent for MS. | ||||||||||||||||||||
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References
- [1]. Sarswat A, et al. Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem. 2017 May 1;25(9):2643-2656. [Content Brief]
- [2]. Caprariello, A. V., et al., (2018). Biochemically altered myelin triggers autoimmune demyelination. Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5528–5533. [Content Brief]
Keywords
