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Results for "

NHE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/H+ Exchanger (NHE) (37) Apoptosis (1) Autophagy (7) COX (4) Isotope-Labeled Compounds (1) Potassium Channel (1) Prostaglandin Receptor (4) Reference Standards (5) SGLT (1) SOD (1) Sodium Channel (2) TRP Channel (4)
By Research Areas:	Cancer (7) Cardiovascular Disease (18) Inflammation/Immunology (5) Metabolic Disease (9) Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

MCE Kits

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Na+/H+ Exchanger (NHE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101840

EIPA Maximum Cited Publications 98 Publications Verification L593754; MH 12-43; Ethylisopropylamiloride	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-15991

Tenapanor 5+ Cited Publications AZD1722; RDX5791	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .

HY-101840A

EIPA hydrochloride Maximum Cited Publications 98 Publications Verification L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-15991A

Tenapanor hydrochloride 5+ Cited Publications AZD1722 hydrochloride; RDX5791 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .

HY-19273

Rimeporide 4 Publications Verification EMD-87580	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-105064D

Zoniporide hydrochloride hydrate 2 Publications Verification CP-597396 hydrochloride hydrate	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-156696

S3226	Na+/H+ Exchanger (NHE)	Metabolic Disease
S3226 is a highly selective *NHE-3* inhibitor (IC₅₀<1 μM) that specifically blocks *NHE-3*-mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms .

HY-18071

BI-9627 3 Publications Verification	Na+/H+ Exchanger (NHE) Autophagy	Cardiovascular Disease
BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against *NHE2* and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca ²⁺ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-174400

SGLT2-IN-2	SGLT SOD Na+/H+ Exchanger (NHE) Autophagy	Cardiovascular Disease
SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, *NHE1, and SOD* enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice .

HY-139313

NHE3-IN-2	Na+/H+ Exchanger (NHE)	Metabolic Disease
NHE3-IN-2 is a Na ⁺/H ⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .

HY-105064

Zoniporide 2 Publications Verification CP-597396	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) is a potent and selective *NHE-1* inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na ⁺ uptake by human *NHE-1*-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-18071A

BI-9627 hydrochloride 3 Publications Verification	Na+/H+ Exchanger (NHE) Autophagy	Cardiovascular Disease
BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against *NHE2* and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca ²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-173517

NHE-1-IN-2	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE-1-IN-2 (compound 7g) is a potent *NHE-1* inhibitor with an IC₅₀ of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure .

HY-100325

NHE3-IN-1	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

HY-120623

BMS-284640	Na+/H+ Exchanger (NHE)	Neurological Disease
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher *NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE*-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats. .

HY-118778

KR-32568	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects .

HY-19273R

Rimeporide (Standard) EMD-87580 (Standard)	Na+/H+ Exchanger (NHE) Reference Standards	Metabolic Disease
Rimeporide (Standard) is the analytical standard of Rimeporide. This product is intended for research and analytical applications. Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

HY-106150

Eniporide EMD-96785	Na+/H+ Exchanger (NHE)	Others
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-19273A

Rimeporide hydrochloride EMD-87580 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-177125

Repunapanor	Na+/H+ Exchanger (NHE)	Neurological Disease
Repunapanor (compound 123) is a potent Na+/H+ exchanger 3 (NHE-3) inhibitor .

HY-105064A

Zoniporide mesylate CP-597396 mesylate	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide mesylate (CP-597396 mesylate) is a potent and selective *NHE-1* inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na ⁺ uptake by human *NHE-1*-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-105402

T 162559	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform *NHE1* with IC₅₀ values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease .

HY-151360

NHE3-IN-3	Sodium Channel	Metabolic Disease
NHE3-IN-3 (Compound 1) is a Na ⁺/H ⁺ exchanger isoform 3 (NHE3) inhibitor with pIC₅₀ of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats .

HY-123659

KR-33028	Na+/H+ Exchanger (NHE) Apoptosis	Cardiovascular Disease Cancer
KR-33028 is a selective *NHE1* inhibitor. KR-33028 reduces hypoxia-induced necrosis and apoptosis in H9c2 cells. KR-33028 inhibits hypoxia-induced increases in cytoplasmic and mitochondrial Ca ²⁺ levels and cytochrome c release. KR-33028 improves cardiac contractility, reduces lactate dehydrogenase release, and increases tissue ATP, creatine phosphate, and glycogen levels. KR-33028 can be used in research on cancers such as cardioblastoma and cardiovascular diseases such as ischemic stroke .

HY-105064B

Zoniporide hydrochloride CP-597396 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-105064DR

Zoniporide hydrochloride hydrate (Standard) CP-597396 hydrochloride hydrate (Standard)	Reference Standards Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (hydrochloride hydrate) (Standard) is the analytical standard of Zoniporide (hydrochloride hydrate). This product is intended for research and analytical applications. Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM) .

HY-125144

BIIB 513	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC₅₀ of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load .

HY-132181

Dimethylamiloride hydrochloride	Na+/H+ Exchanger (NHE)	Inflammation/Immunology
Dimethylamiloride hydrochloride is a Na ⁺/H ⁺ exchanger *NHE* inhibitor with K_i values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research .

HY-13412

Cariporide (mesilate) HOE-642	Potassium Channel Sodium Channel	Cardiovascular Disease
Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1 .

HY-105064C

Zoniporide dihydrochloride CP-597396 dihydrochloride	Na+/H+ Exchanger (NHE)	Cancer
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits *NHE1* dependent 22Na ⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity .

HY-105064R

Zoniporide (Standard) CP-597396 (Standard)	Reference Standards Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (Standard) is the analytical standard of Zoniporide. This product is intended for research and analytical applications. Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-122525A

Sabiporide hydrochloride BIIB 722 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Neurological Disease
Sabiporide hydrochloride is a *NHE-1* inhibitor (K_i: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death .

HY-106150A

Eniporide mesylate	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content .

HY-W704968

2-Oxo-zoniporide hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
2-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury .

HY-W705589

Rimeporide-15N3 hydrochloride EMD-87580-15N3 hydrochloride	Isotope-Labeled Compounds Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide- ¹⁵N₃ (hydrochloride) (EMD-87580- ¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-19862

TY-51924 ethanol sodium	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
TY-51924 ethanol sodium is a highly selective *NHE-1* inhibitor (IC₅₀ = 0.095 μM). TY-51924 ethanol sodium can significantly reduce the infarct size and myocardial enzyme release. TY-51924 ethanol sodium is commonly used in the study of ischemia-reperfusion injury .

HY-163365

UTX-143	Na+/H+ Exchanger (NHE)	Cancer
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity .

HY-101840AR

EIPA hydrochloride (Standard) L593754 hydrochloride (Standard); MH 12-43 hydrochloride (Standard); Ethylisopropylamiloride hydrochloride (Standard)	Reference Standards TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-101840R

EIPA (Standard) L593754 (Standard); MH 12-43 (Standard); Ethylisopropylamiloride (Standard)	Reference Standards TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

Eniporide EMD-96785	Biochemical Assay Reagents
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

Nhe I
MCE Nhe I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Bmt I.

Rimeporide-15N3 hydrochloride
Rimeporide- ¹⁵N₃ (hydrochloride) (EMD-87580- ¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

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HY-P810256

	NHE-6 Antibody (YA9600)	WB, ELISA	human
	NHE-6 Antibody (YA9600) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NHE-6.

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