852146-73-7
852146-73-7
Chemical Structure
KR-32568
- CAS No.: 852146-73-7
- Formula:C13H12FN3O2
- Molecular Weight:261.25
IUPAC Name: N-carbamimidoyl-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide
InChIKey: DTLDHYBZLVASJQ-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(C2=CC=C(O2)C(NC(N)=N)=O)=C1)C
Biological Activity: KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KR-32568 | 99.74% | KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects. | ||||||||||||||||||||
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References
- [1]. Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. [Content Brief]
- [2]. Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. [Content Brief]
Keywords
