Search Result

Results for "

NK2 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (61) Apoptosis (1) Bcl-2 Family (1) Cadherin (1) Calcium Channel (1) Caspase (1) Cyclin G-associated Kinase (GAK) (1) Endogenous Metabolite (2) Neprilysin (1) Reference Standards (2) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (18) Infection (1) Inflammation/Immunology (11) Metabolic Disease (2) Neurological Disease (48)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013375

Thiorphan 3 Publications Verification	Neprilysin	Neurological Disease
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC₅₀ of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .

HY-P0197

Neurokinin A 3 Publications Verification Substance K; Neurokinin α; Neuromedin L; NKA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-101249

L-732138	Neurokinin Receptor	Neurological Disease Cancer
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action .

HY-106910

Saredutant 4 Publications Verification SR 48968; SR 48968C	Neurokinin Receptor	Neurological Disease Endocrinology
Saredutant is a selective **NK2 receptor** antagonist.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent *NK2R* agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues .

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-107691

GR 159897	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [ ³H]GR100679 to *human NK₂* (hNK₂)-CHO cells and rat colon membranes with pK_i**s of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease
GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .

HY-P0006

Eledoisin Eledone peptide	Neurokinin Receptor	Others
Eledoisin (Eledone peptide) is a specific agonist of *NK2* and NK3 receptors.

HY-P1031

[bAla8]-Neurokinin A(4-10) MEN 10210	Neurokinin Receptor	Endocrinology
[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P0197A

Neurokinin A TFA 3 Publications Verification Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P1276A

Men 10376 TFA 1 Publications Verification Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor .

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, neurokinin-1 (NK₁) receptor antagonist with IC₅₀ of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK₂, NK₃ receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .

HY-151413

MEN 10207 1 Publications Verification	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P0236A

Neurokinin A(4-10) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective *NK-2* (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P0236

Neurokinin A(4-10)	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder **NK-2 receptor**. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective **NK-2 tachykinin receptor** (Neurokinin Receptor) agonist .

HY-19405

UK-224671	Neurokinin Receptor	Others
UK-224671 is a potent and selective *NK2* receptor antagonist. UK-224671 is affected by P-gp efflux and poor intrinsic membrane permeability, resulting in low oral bioavailability .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent **NK2 receptor** antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at *NK2* and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-128537

DNK-333	Neurokinin Receptor	Inflammation/Immunology
DNK-333 is a potent and balanced dual NK1 and **NK2 receptor antagonist with IC₅₀** values of 4.8 nM and 5.5 nM, respectively. DNK-333 blocks the Neurokinin A (NKA) (HY-P0197)-induced bronchoconstriction in asthma .

HY-151413A

MEN 10207 acetate	Neurokinin Receptor	Neurological Disease
MEN 10207 (acetate) is a selective antagonist of the *NK-2* tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10)-induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10)-induced enhancement of bronchoconstriction in anesthetized guinea pigs .

HY-120928

S 16474	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
S 16474 is a cyclic peptide with antagonistic effects on NK1 and *NK2* receptors. S 16474 can be used in the study of neurogenic inflammation .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-118378

ZD6021	Neurokinin Receptor	Neurological Disease Endocrinology
ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with K_i values of 0.12 nM for NK1 and 0.62 nM for *NK2. At a concentration of 100 nM, ZD6021 has a pK_B* value of 8.9 for human pulmonary artery NK1 receptors, and a pK_B value of 7.3 for human bronchial *NK2* receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED₅₀ of 0.5 mg/kg, and also decreases *NK2* mediated bronchoconstriction, with an ED₅₀ of 13 mg/kg .

HY-14770

Ibodutant MEN 15596	Neurokinin Receptor	Neurological Disease Endocrinology
Ibodutant (MEN 15596) is a potent and selective tachykinin NK2 receptor antagonist with a pK_i of 10.1.

HY-P1017

MDL 29913	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
MDL 29913, a cyclic pseudopeptide, is a competitive *NK₂* tachykinin receptor selective antagonist, with a pA₂ of 8.66 .

HY-106910R

Saredutant (Standard) SR 48968 (Standard); SR 48968C (Standard)	Neurokinin Receptor Reference Standards	Neurological Disease Endocrinology
Saredutant (Standard) is the analytical standard of Saredutant. This product is intended for research and analytical applications. Saredutant is a selective NK2 receptor antagonist.

HY-P3861

Biotin-Neurokinin A	Neurokinin Receptor	Neurological Disease
Biotin-Neurokinin A is a biotinylated Neurokinin A (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P10588

WIN 66306	Neurokinin Receptor	Others
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and *NK2* receptors .

HY-116958

SCH 206272	Neurokinin Receptor	Inflammation/Immunology
SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (K_i = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active .

HY-157743

SCH 60057	Neurokinin Receptor	Neurological Disease
SCH 60057 (Compound 7) is a neurokinin (NK) receptor inhibitor that can be isolated from Acremonium sp., with IC₅₀ values of 6 μM and 12 μM for NK₁ and NK₂, respectively .

HY-P2603

Bz-Dab(NBD)-AwFpP-Nle-NH2	Neurokinin Receptor	Neurological Disease
Bz-Dab(NBD)-AwFpP-Nle-NH2 (Compound 5B) is a potent fluorescent antagonist of **NK2 receptor, with a pK_i** of 8.87 nM (Ex=340 nm, Em=505 nm) .

HY-105462

MDL 105212A	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
MDL 105212A is a potent and orally active nonpeptide neurokinin receptor (NK-1/NK-2) tachykinin receptor antagonist. MDL 105212A can be used for the researches of inflammation, immunology and neurological disease, such as asthma .

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)	Neurokinin Receptor	Inflammation/Immunology
[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM .

HY-117053

ZM 253270	Neurokinin Receptor	Neurological Disease
ZM 253270 is a species-selective non-peptide *NK-2* receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [ ³H]NKA to native or cloned *NK-2R* from hamster bladder (K_i=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [ ³H]NKA to cloned human *NK-2R* .

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM .

HY-P2436

L-659837	Neurokinin Receptor	Neurological Disease
L-659837 is a *NK2* receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at *NK2* and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

Cat. No.	Product Name	Target	Research Area

HY-P0197

Neurokinin A 3 Publications Verification Substance K; Neurokinin α; Neuromedin L; NKA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent *NK2R* agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues .

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease
GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .

HY-P0006

Eledoisin Eledone peptide	Neurokinin Receptor	Others
Eledoisin (Eledone peptide) is a specific agonist of *NK2* and NK3 receptors.

HY-P1031

[bAla8]-Neurokinin A(4-10) MEN 10210	Neurokinin Receptor	Endocrinology
[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P0197A

Neurokinin A TFA 3 Publications Verification Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P1276A

Men 10376 TFA 1 Publications Verification Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor .

HY-151413

MEN 10207 1 Publications Verification	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P0236A

Neurokinin A(4-10) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective *NK-2* (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P0236

Neurokinin A(4-10)	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder **NK-2 receptor**. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective **NK-2 tachykinin receptor** (Neurokinin Receptor) agonist .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent **NK2 receptor** antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at *NK2* and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-151413A

MEN 10207 acetate	Neurokinin Receptor	Neurological Disease
MEN 10207 (acetate) is a selective antagonist of the *NK-2* tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10)-induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10)-induced enhancement of bronchoconstriction in anesthetized guinea pigs .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1017

MDL 29913	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
MDL 29913, a cyclic pseudopeptide, is a competitive *NK₂* tachykinin receptor selective antagonist, with a pA₂ of 8.66 .

HY-P3861

Biotin-Neurokinin A	Neurokinin Receptor	Neurological Disease
Biotin-Neurokinin A is a biotinylated Neurokinin A (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-P10588

WIN 66306	Neurokinin Receptor	Others
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and *NK2* receptors .

HY-P2603

Bz-Dab(NBD)-AwFpP-Nle-NH2	Neurokinin Receptor	Neurological Disease
Bz-Dab(NBD)-AwFpP-Nle-NH2 (Compound 5B) is a potent fluorescent antagonist of **NK2 receptor, with a pK_i** of 8.87 nM (Ex=340 nm, Em=505 nm) .

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)	Neurokinin Receptor	Inflammation/Immunology
[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM .

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM .

HY-P2436

L-659837	Neurokinin Receptor	Neurological Disease
L-659837 is a *NK2* receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide agonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at *NK2* and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2593

L-659874	Neurokinin Receptor	Neurological Disease
L-659874 is a selective *NK2* receptor antagonist with an IC₅₀ value of 0.49 μM in hamsters. L-659874 inhibits *NK2* receptor-mediated hydrolysis of inositol phospholipids. L-659874 could be used for research on the correlation between pain signal transduction and smooth muscle responses. .

HY-P1278B

GR 64349 acetate	Neurokinin Receptor	Neurological Disease Endocrinology
GR 64349 acetate is a selective neurokinin 2 (NK2) receptor agonist. GR 64349 acetate selectively activates the *NK-2* receptor subtype. GR 64349 acetate activates tonic and rhythmic bladder contractions of the micturition reflex. GR 64349 acetate does not inhibit rhythmic bladder contraction activation induced by normal saline. GR 64349 acetate induces inward currents .

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for NK-1, *NK-2*,and NK-3 receptor, respectively .

HY-P11075

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)	Neurokinin Receptor	Metabolic Disease
[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective *NK2R* agonist with an EC₅₀ of 3.7  nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9554

WIN-64821	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Neurokinin Receptor Endogenous Metabolite Calcium Channel
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

NK2 receptor

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products