1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Men 10376 TFA

Men 10376 TFA (Synonyms: Neurokinin-2 receptor antagonist (TFA))

Cat. No.: HY-P1276A Purity: 99.76%
Handling Instructions

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Men 10376 TFA Chemical Structure

Men 10376 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 440 In-stock
Estimated Time of Arrival: December 31
10 mg USD 740 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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Description

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1].

IC50 & Target

Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]

In Vitro

Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].

In Vivo

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1.43 mg/mL (1.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8366 mL 4.1832 mL 8.3665 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1195.25

Formula

C₅₉H₆₉F₃N₁₂O₁₂

Sequence

Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2

Sequence Shortening

DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Men 10376 TFA
Cat. No.:
HY-P1276A
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Men 10376 TFA

Cat. No.: HY-P1276A