1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Men 10376

Men 10376 (Synonyms: Neurokinin-2 receptor antagonist)

Cat. No.: HY-P1276
Handling Instructions

Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

For research use only. We do not sell to patients.

Men 10376 Chemical Structure

Men 10376 Chemical Structure

CAS No. : 135306-85-3

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Description

Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

IC50 & Target

Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]

In Vitro

Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].

In Vivo

Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1081.22

Formula

C₅₇H₆₈N₁₂O₁₀

CAS No.

135306-85-3

Sequence

Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2

Sequence Shortening

DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2

SMILES

NCCCC[[email protected]@H](C(N)=O)NC([[email protected]@H](CC1=CNC2=C1C=CC=C2)NC([[email protected]](NC([[email protected]](C(C)C)NC([[email protected]](NC([[email protected]@H](NC([[email protected]@H](N)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CNC5=C4C=CC=C5)=O)=O)CC6=CNC7=C6C=CC=C7)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Men 10376
Cat. No.:
HY-P1276
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Men 10376

Cat. No.: HY-P1276