[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
Based on 1 Customer Validation
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 149270-28-0
- Formula: C39H64N8O10
- Molecular Weight:804.97
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
![[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3849.gif "Click to View [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
NK2R |
In Vivo
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (0.3 μg/kg i.v. or 100 μg/kg i.n.) also increases bladder and colorectal pressures[1].
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (10-100 μg/kg, i.v., four times daily for six consecutive days) elicits micturition and defecation, emesis and hypotension in conscious dogs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Conscious dogs[2]
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Dosage:10-100 μg/kg
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Administration:Intravenous injection (i.v.), four times daily for six consecutive days.
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Result:Elicited NK2 receptor-mediated micturition defecation and NK1 receptor-mediated emesis and hypotension.
Chemical Information
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CAS No. 149270-28-0
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Appearance Solid
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Molecular Weight 804.97
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Formula C39H64N8O10
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Color White to off-white
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Synonyms
LMN-NKA
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Sequence
Asp-Lys-Phe-Val-Gly-Leu(N-Me)-Nle
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Sequence Shortening
DKFVGL(N-Me)-Nle
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (31.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rupniak NMJ, et al. Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4-10) on bladder and colorectal activity in minipigs. Neuropeptides. 2019 Oct;77:101956. [Content Brief]
[2]. Rupniak NMJ, et al. [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs. J Pharmacol Exp Ther. 2018 Jul;366(1):136-144. [Content Brief]
[3]. Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2423 mL | 6.2114 mL | 12.4228 mL | 31.0571 mL |
| 5 mM | 0.2485 mL | 1.2423 mL | 2.4846 mL | 6.2114 mL | |
| 10 mM | 0.1242 mL | 0.6211 mL | 1.2423 mL | 3.1057 mL | |
| 15 mM | 0.0828 mL | 0.4141 mL | 0.8282 mL | 2.0705 mL | |
| 20 mM | 0.0621 mL | 0.3106 mL | 0.6211 mL | 1.5529 mL | |
| 25 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2423 mL | |
| 30 mM | 0.0414 mL | 0.2070 mL | 0.4141 mL | 1.0352 mL |
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Related Classifications
HY-P3849 Related Classifications
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