149270-28-0
![[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p3849.gif "[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) Chemical Structure")
149270-28-0
Chemical Structure
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
Synonym(s): LMN-NKA
- CAS No.: 149270-28-0
- Formula:C39H64N8O10
- Molecular Weight:804.97
InChIKey: PLJWDMCXCWRSKI-HLYNNXGTSA-N
SMILES: OC(C[C@H](N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N(C)[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCC)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O
Biological Activity: [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) | 99.89% | [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Rupniak NMJ, et al. Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4-10) on bladder and colorectal activity in minipigs. Neuropeptides. 2019 Oct;77:101956. [Content Brief]
- [2]. Rupniak NMJ, et al. [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs. J Pharmacol Exp Ther. 2018 Jul;366(1):136-144. [Content Brief]
- [3]. Sara Good, et al. [Lys5, MeLeu9, Nle10]NKA-4-10. Reference Module in Biomedical Sciences. 2019.
