1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Neurokinin A(4-10) TFA

Neurokinin A(4-10) TFA 

Cat. No.: HY-P0236A Purity: 98.48%
Handling Instructions

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neurokinin A(4-10) TFA Chemical Structure

Neurokinin A(4-10) TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 588 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Other Forms of Neurokinin A(4-10) TFA:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1].

IC50 & Target

NK2 receptor[1]

In Vitro

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
Molecular Weight

880.93

Formula

C₃₆H₅₅F₃N₈O₁₂S

Sequence

Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

Sequence Shortening

DSFVGLM-NH2

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
Neurokinin A(4-10) TFA
Cat. No.:
HY-P0236A
Quantity:

Neurokinin A(4-10) TFA

Cat. No.: HY-P0236A