![[Nphe1]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p1320.gif "Click to View [Nphe1]Nociceptin(1-13)NH2 Product Detail")
![[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p0192.gif "Click to View [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
Nociceptin
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "Nociceptin" in MCE Product Catalog:
5
Target:
Research Areas:
2
Target:
Research Areas:
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models .
2
2 Cited Publications
Cat. No.: HY-18618A
Target:
Research Areas:
SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-,?κ- and?δ-receptors with Ki values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .
1
1 Cited Publications
Target:
Research Areas:
BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic .
Target:
Research Areas:
(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ .
Target:
Research Areas:
BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects .
Target:
Research Areas:
J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist (Ki: cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors .
Target:
Research Areas:
SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .
Cat. No.: HY-P1302
CAS No.: 178249-41-7
Target:
Research Areas:
Cat. No.: HY-P1317A
Target:
Research Areas:
Cat. No.: HY-P1320
CAS No.: 267234-08-2
Target:
Research Areas:
Cat. No.: HY-P1319
CAS No.: 178249-42-8
Target:
Research Areas:
Cat. No.: HY-156972
CAS No.: 2099681-43-1
Target:
Research Areas:
NOP agonist-1(compound 4) is a nociceptin opioid receptor (NOP) partial agonist. NOP agonist-1attenuate parkinsonian disabilities in 6-OHDA hemilesioned rats .
Cat. No.: HY-P3839
CAS No.: 207392-60-7
Target:
Research Areas:
Cat. No.: HY-P0192
CAS No.: 213130-17-7
Target:
Research Areas:
Cat. No.: HY-10886
CAS No.: 1028969-49-4
Target:
Research Areas:
MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research .
Cat. No.: HY-122681
CAS No.: 857262-16-9
Synonyms: SR-16435 free base
Target:
Research Areas:
SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16434 can relieve pain .
Cat. No.: HY-P1316A
CAS No.: 408305-09-9
Target:
Research Areas:
Cat. No.: HY-14124
CAS No.: 919482-44-3
Target:
Research Areas:
MK-5757 is a Nociceptin/Orphanin FQ Peptide Receptor antagonist. ORL1 antagonist 3 can improve cerebral blood flow disorders and ischemic damage, and alleviate abnormal neurological symptoms. ORL1 antagonist 3can be used for the research of neurological disease, such as traumatic brain injury .
Cat. No.: HY-P1302A
Target:
Research Areas:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
