BAN ORL 24

Cat. No.: HY-13222 Purity: 98.08%: FAQs
Data Sheet SDS COA Handling Instructions

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with K_I value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic.

For research use only. We do not sell to patients.

BAN ORL 24 Chemical Structure

CAS No. : 1401463-54-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 174	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 174	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 101	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 158	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 594	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1056	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of BAN ORL 24:

BAN ORL 24 free base Get quote

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Purity & Documentation
References
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Description

IC₅₀ & Target

Ki: 0.24 nM (NOP in CHO cell)^[1].
IC50: 50 μM (NOR); 0.224 μM (MOR)^[2]

In Vitro

BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC₅₀ values of 50 μM and 0.224 μM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice^[3]
Dosage:	10 mg/kg
Administration:	10 mg/kg; i.v.
Result:	Caused inhibition of BPRIM97-induced antinociception at 90-min postinjection. Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min.

Molecular Weight

506.51

Appearance

Solid

Formula

C₂₇H₃₇Cl₂N₃O₂

CAS No.

1401463-54-4

SMILES

O=C([C@@H]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(CC3)OCC5=C4C=CC=C5.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (394.86 mM; Need ultrasonic)

H₂O : 100 mg/mL (197.43 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9743 mL	9.8715 mL	19.7429 mL
5 mM	0.3949 mL	1.9743 mL	3.9486 mL
10 mM	0.1974 mL	0.9871 mL	1.9743 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS
Solubility: 100 mg/mL (197.43 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (9.87 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (9.87 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (9.87 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 98.09%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (256 KB) HNMR (229 KB) RP-HPLC (173 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50. [Content Brief]

[2]. Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol [Content Brief]

[3]. Chao, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology 166, 107678 (2020).

BAN ORL 24 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

BAN ORL 241401463-54-4BAN ORL24BAN ORL-24Opioid Receptornociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)CHO cellanalgesiccancerInhibitorinhibitorinhibit

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