BAN ORL 24 free base
Based on 1 publication(s) in Google Scholar
BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic.
For research use only. We do not sell to patients.
- CAS No.: 475150-69-7
- Formula: C27H35N3O2
- Molecular Weight:433.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAN ORL 24 free base
MoreAll Opioid Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.15 nM
Compound: 24
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Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells
Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells
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[PMID: 16451050] |
| CHO | IC50 |
0.27 nM
Compound: 24
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Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells
Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells
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[PMID: 16451050] |
| CHO | IC50 |
2500 nM
Compound: 24
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Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells
Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells
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[PMID: 16451050] |
| CHO | IC50 |
6700 nM
Compound: 24
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Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells
Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells
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[PMID: 16451050] |
| CHO | EC50 |
>1000 nM
Compound: 24
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Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells
Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells
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[PMID: 16451050] |
| CHO | IC50 |
>10000 nM
Compound: 24
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Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells
Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells
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[PMID: 16451050] |
BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC50 values of 50 μM and 0.224 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 475150-69-7
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Molecular Weight 433.59
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Formula C27H35N3O2
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SMILES
O=C([C@@H]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(CC3)OCC5=C4C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Neurotherapeutics
LY2940094, an NOPR antagonist, promotes oligodendrocyte generation and myelin recovery in an NOPR independent manner. [Abstract]2024 Sep;21(5):e00424. PMID: 39004556
Purity & Documentation
References
[1]. Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol [Content Brief]
[3]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAN ORL 24 free base Related Classifications
HY-13222A Related Classifications
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