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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
Oct-1
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "Oct-1" in MCE Product Catalog:
44
Category:
Alkaloids Pyrrole Alkaloids Leguminosae Plants Crotalaria pallida Ait. Disease Research Fields Cancer
Target:
17
17 Cited Publications
Cat. No.: HY-B0193A
CAS No.: 19237-84-4
Target:
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders [1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
1
Category:
Alkaloids Corydalis yanhusuo W. T. Wang Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae
Target:
Synonyms: 1,1'-Diethyl-2,2'-cyanine iodide; Decynium 22; Diethylcyanine iodide; Eastman 7851
연구분야:
Pseudoisocyanine iodide (1,1'-Diethyl-2,2'-cyanine iodide) is an inhibitor of organic cation transporters (OCT1, OCT2, OCT3) and plasma membrane monoamine transporter (PMAT). Pseudoisocyanine iodide has antidepressant activity [1] .
Cat. No.: HY-B0306
CAS No.: 14222-60-7
Synonyms: Protionamide
Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy [1] .
Category:
Alkaloids Piperidine Alkaloids Ranunculaceae Other Diseases Plants Disease Research Fields
Target:
Cat. No.: HY-W010410
CAS No.: 3391-86-4
Category:
Target:
Cat. No.: HY-W781133
CAS No.: 106343-54-8
Synonyms: cis-[Pt(NH3)2N1-pyridineCl]Cl
Target:
연구분야:
cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters [1] .
Cat. No.: HY-106055
CAS No.: 74817-61-1
Murabutide is an immunomodulator and also a NOD2 receptor agonist . Murabutide enhances the signal transduction of ATR and NOD2, mediates the activation of the DDR pathway, and thereby repairs radiation-induced DNA double-strand breaks. Murabutide inhibits radiation-induced cell apoptosis and protects cells and mice from radiation-induced toxic damage. Murabutide induces the expression and DNA-binding activity of Oct-1 in macrophages, thereby inhibiting the transcription and replication of HIV-1. Murabutide reduces the expression levels of CD4 and CCR5 on the surface of macrophages, and induces the secretion of β-chemokines, TNF-α and IL-6. Murabutide enhances non-specific viral resistance and targets reticuloendothelial cells. Murabutide can be used in research related to radiation-induced damage and human immunodeficiency virus type 1 infection [1] .
Cat. No.: HY-RS13061
Target:
연구분야:
SLC22A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC22A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Cat. No.: HY-W010410S
CAS No.: 1335435-98-7
Cat. No.: HY-B0193AR
CAS No.: 19237-84-4
Prazosin (hydrochloride) (Standard) is the analytical standard of Prazosin (hydrochloride). This product is intended for research and analytical applications. Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders [1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
Cat. No.: HY-B0306S
CAS No.: 1330261-26-1
Synonyms: Protionamide-d5
Cat. No.: HY-B0306R
CAS No.: 14222-60-7
Synonyms: Protionamide (Standard)
Target:
연구분야:
Prothionamide (Standard) is the analytical standard of Prothionamide (HY-B0306). This product is intended for research and analytical applications. Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy [1] .
Cat. No.: HY-P87293
Synonyms: FLJ42836 antibody; NF A1 antibody; NF-A1 antibody; Oct 1 antibody; Oct 1B antibody; Oct-1 antibody; Oct1 antibody; Octamer binding protein 1 antibody; Octamer binding transcription factor 1 antibody; Octamer-binding protein 1 antibody
Cat. No.: HY-100057
CAS No.: 125481-61-0
Synonyms: 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215
연구분야:
BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
Synonyms: (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)
Category:
Cat. No.: HY-P83828A
Synonyms: Oct1; HOct1; Oct1_cds; SLC22A1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
