106343-54-8
106343-54-8
Chemical Structure
cDPCP
Synonym(s): cis-[Pt(NH3)2N1-pyridineCl]Cl
- CAS No.: 106343-54-8
- Formula:C5H11Cl2N3Pt
- Molecular Weight:379.15
InChIKey: JDWBOMGRVMIMAU-UHFFFAOYSA-L
SMILES: [Cl-][Pt+2]([NH3])([NH3])[N]1=CC=CC=C1.[Cl-]
Biological Activity: cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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cDPCP | 99.9% | cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters. | ||||||||||||||||||||
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References
- [1]. Lovejoy KS, et al. Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans. 2009 Dec 28;(48):10651-9. [Content Brief]
- [2]. Lovejoy KS, et al. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8902-7. [Content Brief]
Keywords
