125481-61-0
Chemical Structure
BMY 28674
Synonym(s): 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215
- CAS No.: 125481-61-0
- Formula:C21H31N5O3
- Molecular Weight:401.50
IUPAC Name: 6-hydroxy-8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione
InChIKey: KOZNAHJIJGCFJJ-UHFFFAOYSA-N
SMILES: O=C(N(CCCCN1CCN(C2=NC=CC=N2)CC1)C(C3)=O)C(O)C43CCCC4
Biological Activity: BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
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BMY 28674 | BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner. | |||||||||||||||||||||
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BMY 28674-d8 | BMY 28674-d8 is the deuterium labeled BMY 28674. | |||||||||||||||||||||
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