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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
PKU
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "PKU" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-A0124A
CAS No.: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride
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JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) .
Cat. No.: HY-A0124AR
CAS No.: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)
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Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .
Cat. No.: HY-A0124
CAS No.: 62989-33-7
Synonyms: (6R)-BH4; (6R)-Tetrahydro-L-biopterin
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Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .
Cat. No.: HY-P2964
CAS No.: 69403-12-9
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Phenylalanine dehydrogenase is an NAD +-dependent oxidoreductase targeting L-phenylalanine. Phenylalanine dehydrogenase catalyzes deamination to phenylpyruvate and NADH as part of amino acid metabolism regulation. Phenylalanine dehydrogenase is promising for research of phenylketonuria (PKU) .
Cat. No.: HY-158161
CAS No.: 3032920-98-9
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JN-170 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC50=47 nM). Furthermore, at a concentration of 35 μM, JN-170 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. JN-170 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. JN-170 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia .
Cat. No.: HY-144856S1
CAS No.: 2747956-15-4
Synonyms: (6R)-BH4-d3; (6R)-Tetrahydro-L-biopterin-d3
Cat. No.: HY-176873
CAS No.: 3102931-05-2
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SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC50 of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU) .
Cat. No.: HY-RS09979
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PAH Human Pre-designed siRNA Set A contains three designed siRNAs for PAH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702737
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TLK2; tousled-like kinase 2; serine/threonine-protein kinase tousled-like 2; MGC44450; PKU ALPHA; serine/threonine kinase; PKU-ALPHA
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Cat. No.: HY-P76676
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1; TLK1; KIAA0137
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Cat. No.: HY-179581
CAS No.: 2962069-39-0
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SLC6A19-IN-4 is an allosteric-competitive and orally active B 0AT1 inhibitor. SLC6A19-IN-4 inhibits both human and mouse B 0AT1 with IC50 values of 513 nM and 295 nM, respectively. SLC6A19-IN-4 exhibits excellent metabolic stability. SLC6A19-IN-4 significantly increases urinary phenylalanine (Phe) excretion and reduces plasma Phe levels through dual inhibition of B 0AT1 in both the intestine (reducing absorption) and kidney (promoting excretion) in vivo. SLC6A19-IN-4 can be used for phenylketonuria (PKU) and other disorders involving SLC6-family transporters research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
