2747956-15-4
Chemical Structure
Sapropterin-d3
Synonym(s): (6R)-BH4-d3; (6R)-Tetrahydro-L-biopterin-d3
- CAS No.: 2747956-15-4
- Formula:C9H12D3N5O3
- Molecular Weight:244.27
IUPAC Name: 2-amino-6-((1R,2S)-1,2-dihydroxypropyl-3,3,3-d3)-5,6,7,8-tetrahydropteridin-4(1H)-one
InChIKey: FNKQXYHWGSIFBK-REYWBDFHSA-N
SMILES: O=C1N=C(N)NC2=C1NC([C@@H](O)[C@@H](O)C([2H])([2H])[2H])CN2
Biological Activity: Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU)[1][2].
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Sapropterin-d3 | Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU). | |||||||||||||||||||||
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Sapropterin | Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE). | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18(3):1862-1879. [Content Brief]
Keywords
