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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Pgrmc1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Pgrmc1" in MCE Product Catalog:
Cat. No.: HY-115625
CAS No.: 1375078-57-1
Research Areas:
AG-205 is a progesterone receptor membrane component 1 (PGRMC1) antagonist and CGT inhibitor, with an IC50 of 50 μM against rat CGT. AG-205 exhibits antimitotic, antimigratory and anti-invasive activities. AG-205 increases the expression of genes encoding cholesterol biosynthesis pathway or steroidogenic enzymes. AG-205 promotes the regulation of cell cycle by apoptosis and reduces the migratory and invasive capacities of ovarian and breast cancer cells. AG-205 can be used in research related to renal cancer and breast cancer [1] .
Cat. No.: HY-121012
CAS No.: 442656-02-2
Research Areas:
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway [1].
Cat. No.: HY-RS10399
Target:
Research Areas:
PGRMC1 Human Pre-designed siRNA Set A contains three designed siRNAs for PGRMC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-119386
CAS No.: 1644629-60-6
Target:
Research Areas:
SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (Ki: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca 2+ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease [1].
Cat. No.: HY-RS20577
Target:
Research Areas:
Pgrmc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgrmc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27085
Target:
Research Areas:
Pgrmc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pgrmc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-120008
CAS No.: 2095551-67-8
Target:
Research Areas:
SAS-1121 is a subtype-selective sigma 2 receptor/PGRMC1 ligand with a Ki of 16.2 nM. SAS-1121 is 574-fold selective for the signma 2 receptor over the sigma 1 receptor. SAS-1121 is a tertiary amine. SAS-1121 can be studied in neurology-related research [1].
Cat. No.: HY-116968
CAS No.: 2089059-30-1
Target:
Research Areas:
JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease [1].
Cat. No.: HY-P87283
Synonyms: HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; Pgrmc antibody; Pgrmc1 antibody; Progesterone binding protein antibody; Progesterone receptor membrane component 1 antibody
Cat. No.: HY-P87283A
Synonyms: HPR6.6 antibody; Membrane associated progesterone receptor component 1 antibody; Membrane-associated progesterone receptor component 1 antibody; mPR antibody; PGRC1_HUMAN antibody; Pgrmc antibody; Pgrmc1 antibody; Progesterone binding protein antibody; Progesterone receptor membrane component 1 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
