442656-02-2
Chemical Structure
(rac)-AG-205
- CAS No.: 442656-02-2
- Formula:C22H23ClN6OS
- Molecular Weight:454.98
IUPAC Name: 2-((1-(4-chlorophenyl)-1H-tetrazol-5-yl)thio)-1-(2,8-dimethyl-1,2,3,4,4a,9b-hexahydro-5H-pyrido[4,3-b]indol-5-yl)ethan-1-one
InChIKey: GJNBAISSZRNGTM-UHFFFAOYSA-N
SMILES: CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O
Biological Activity: (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].
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(rac)-AG-205 | (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway. | |||||||||||||||||||||
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Keywords
