1375078-57-1
Chemical Structure
AG-205
- CAS No.: 1375078-57-1
- Formula:C22H23ClN6OS
- Molecular Weight:454.98
IUPAC Name: 2-((1-(4-chlorophenyl)-1H-tetrazol-5-yl)thio)-1-((4aS,9bR)-2,8-dimethyl-1,2,3,4,4a,9b-hexahydro-5H-pyrido[4,3-b]indol-5-yl)ethan-1-one
InChIKey: GJNBAISSZRNGTM-UYAOXDASSA-N
SMILES: CC1=CC2=C(C=C1)N([C@@]3([H])[C@]2([H])CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O
Biological Activity: AG-205 is a progesterone receptor membrane component 1 (PGRMC1) antagonist and CGT inhibitor, with an IC50 of 50 μM against rat CGT. AG-205 exhibits antimitotic, antimigratory and anti-invasive activities. AG-205 increases the expression of genes encoding cholesterol biosynthesis pathway or steroidogenic enzymes. AG-205 promotes the regulation of cell cycle by apoptosis and reduces the migratory and invasive capacities of ovarian and breast cancer cells. AG-205 can be used in research related to renal cancer and breast cancer[1][2][3].
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AG-205 | 99% | AG-205 is a progesterone receptor membrane component 1 (PGRMC1) antagonist and CGT inhibitor, with an IC50 of 50 μM against rat CGT. AG-205 exhibits antimitotic, antimigratory and anti-invasive activities. AG-205 increases the expression of genes encoding cholesterol biosynthesis pathway or steroidogenic enzymes. AG-205 promotes the regulation of cell cycle by apoptosis and reduces the migratory and invasive capacities of ovarian and breast cancer cells. AG-205 can be used in research related to renal cancer and breast cancer. | ||||||||||||||||||||
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- [1]. Wang-Eckhardt L, et al. The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide. Cells. 2021;10(12):3520. Published 2021 Dec 13. [Content Brief]
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[2]. Will EA, et al. AG 205, a PGRMC1 Antagonist, Ablates Progesterone’s Ability to Block Oxidative Stress-Induced Apoptosis of Human Granulosa/Luteal Cells. Biology of reproduction. 2017.
- [3]. Thieffry C, et al. AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins. Biomolecules. 2021;11(10):1472. Published 2021 Oct 6. [Content Brief]
Keywords
