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Protein Kinase CK2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) Akt (1) Apoptosis (6) Autophagy (4) Bcl-2 Family (1) Casein Kinase (19) Caspase (1) CDK (3) DAPK (1) DYRK (1) Epigenetic Reader Domain (1) ERK (2) Fungal (1) HSP (1) Isotope-Labeled Compounds (1) JNK (1) MDM-2/p53 (1) p38 MAPK (1) PARP (1) Pim (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (4) STAT (1)
By Research Areas:	Cancer (20) Infection (4) Inflammation/Immunology (4)

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Targets Recommended: Creatine Kinase Choline Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14393

Emodin 35+ Cited Publications Frangula emodin	SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-P3815

Casein Kinase 2 Substrate Peptide 2 Publications Verification	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide is a common *CK2* substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .

HY-124833

Quinalizarin	Casein Kinase Apoptosis Fungal Reactive Oxygen Species (ROS) Caspase MDM-2/p53 PARP Bcl-2 Family Akt ERK STAT JNK p38 MAPK CDK	Infection Cancer
Quinalizarin is a protein kinase *CK2* inhibitor with a K_i of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections .

HY-135906

CK2/ERK8-IN-1 2 Publications Verification	Casein Kinase ERK Pim DYRK Apoptosis	Cancer
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (K_i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC₅₀s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (*homeodomain-interacting protein* kinase 2), and DYRK1A with K_i*s of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1* has pro-apoptotic efficacy .

HY-145260

BRD4/CK2-IN-1	Epigenetic Reader Domain Casein Kinase Apoptosis Autophagy	Cancer
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of *BRD4/CK2* (bromodomain-containing protein 4/casein kinase 2), with IC₅₀s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)

HY-P4056A

CIGB-300 acetate P15-Tat acetate	Casein Kinase Apoptosis	Cancer
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-124321

Metralindole hydrochloride	CDK	Cancer
Metralindole hydrochloride is an inhibitor of human cyclin-dependent kinase CDK2 and human protein kinase *CK2* holoenzyme. Metralindole hydrochloride shows good potential as a non-small cell lung cancer inhibitor .

HY-149006

CK156	DAPK	Inflammation/Immunology Cancer
CK156, a chemical probe, is a highly selective death-associated protein kinase (DAPK) inhibitor with IC₅₀s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases .

HY-14393R

Emodin (Standard) 35+ Cited Publications Frangula emodin (Standard)	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase Apoptosis	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-E70625

Casein Kinase 2	Casein Kinase	Cancer
Casein Kinase 2 (CK2) is a serine/threonine protein kinase that is highly conserved among eukaryotes and has roles in many different cellular processes, such as cell survival, cell cycle regulation, cell polarity, stress responses, transcription and translation .

HY-148328

CK2-IN-4	Casein Kinase	Infection Inflammation/Immunology Cancer
CK2-IN-4 (compound 5) is a **protein kinase** (CK2) inhibitor (IC₅₀=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis .

HY-174350

CK2-IN-15	Casein Kinase SARS-CoV	Infection
CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase *CK2* inhibitor with an IC₅₀ value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases .

HY-148763

CK2-IN-6	Casein Kinase	Inflammation/Immunology Cancer
CK2-IN-6 is a potent protein kinase *CK2* inhibitor that can be used in the study of cancer as well as other kinase-related conditions, including inflammation, pain and certain immune diseases .

HY-14393S

Emodin-d4 Frangula emodin-d₄	Isotope-Labeled Compounds SARS-CoV Casein Kinase Autophagy 11β-HSD	Cancer
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-118403

CK2-IN-12	Casein Kinase	Infection Inflammation/Immunology Cancer
CK2-IN-12 (Compound 39) is an inhibitor for **protein kinase CK2 with an IC₅₀** of 0.8 μM .

HY-169629

CK2 inhibitor 4	Casein Kinase	Cancer
CK2 inhibitor 4 (compound 5b) is a protein kinase CK2 inhibitor with IC₅₀ of 3.8 μM. CK2 inhibitor 4 can be used in tumor research .

HY-117332

IQA CGP-029482	Casein Kinase	Cancer
IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor .

HY-124321A

Metralindole	CDK	Cancer
Metralindole is an inhibitor of human cyclin-dependent kinase CDK2 and human protein kinase *CK2* holoenzyme. Metralindole shows good potential as a non-small cell lung cancer inhibitor .

HY-174347

Hsp90-Cdc37-IN-4	HSP Casein Kinase Apoptosis	Cancer
Hsp90-Cdc37-IN-4, a Celastrol (HY-13067) derivative, inhibits the Hsp90-Cdc37 protein-protein interaction (PPI). Hsp90-Cdc37-IN-4 selectively inhibits casein kinase 2 (CK2), reducing phosphorylation of its substrate Cdc37 at Serine 13. Hsp90-Cdc37-IN-4 induces G0/G1 cell cycle arrest and triggers apoptosis via the mitochondrial pathway. Hsp90-Cdc37-IN-4 demonstrates potent anti-breast cancer activity .

HY-143461

CK2 inhibitor 3	Casein Kinase	Cancer
CK2 inhibitor 3 is a potent CK2 inhibitor with IC₅₀ value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases .

HY-171744

CX-5279	Casein Kinase	Cancer
CX-5279 is an efficient and selective CK2 inhibitor with IC₅₀ values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC₅₀ values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279's inhibitory activity against PIM1 is very weak, with a IC₅₀ value of 8.52 μM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia .

Cat. No.	Product Name	Target	Research Area

HY-P3815

Casein Kinase 2 Substrate Peptide 2 Publications Verification	Casein Kinase	Others
Casein Kinase 2 Substrate Peptide is a common *CK2* substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .

HY-P4056A

CIGB-300 acetate P15-Tat acetate	Casein Kinase Apoptosis	Cancer
CIGB-300 acetate (P15-Tat acetate) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 acetate induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase Apoptosis	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase *CK2*. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14393

Emodin 35+ Cited Publications Frangula emodin	Classification of Application Fields Polygonaceae Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification Cancer	SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

HY-14393R

Emodin (Standard) 35+ Cited Publications Frangula emodin (Standard)	Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Phenols Plants Disease Research Fields Source Classification Cancer	Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD
Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Species:	Human (4) Mouse (2)
Tag:	His (3) Tag Free (2) GST (3)
Source:	Sf9 insect cells (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76825

	CK2 alpha/CSNK2A1 Protein, Mouse (sf9) Casein Kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1	Mouse	Sf9 insect cells
	The CK2 α/CSNK2A1 protein is a constitutively active kinase that phosphorylates substrates and regulates cell cycle, apoptosis, transcription, and viral infection. CK2 α/CSNK2A1 also regulates the cellular clock, Wnt signaling, modulates extracellular proteins, and plays a role in viral infection. CK2 alpha/CSNK2A1 Protein, Mouse (sf9) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells, with tag free.

HY-P76826

	CK2 alpha/CSNK2A1 Protein, Mouse (Active, sf9, His-GST) Casein Kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1	Mouse	Sf9 insect cells
	CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CK2 alpha/CSNK2A1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76296

	CK2 alpha/CSNK2A2 Protein, Human (sf9) Casein Kinase II subunit alpha'; CK II alpha'; CSNK2A2; CK2A2	Human	Sf9 insect cells
	The CK2 α/CSNK2A2 protein is the catalytic subunit of the constitutively active serine/threonine protein kinase complex and can phosphorylate a variety of substrates, affecting cell cycle progression, apoptosis, transcription, and viral infection. CK2 alpha/CSNK2A2 Protein, Human (sf9) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells, with tag free.

HY-P76297

	CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) Casein Kinase II subunit alpha'; CK II alpha'; CSNK2A2; CK2A2	Human	Sf9 insect cells
	CSNK2A2 is the catalytic subunit of the serine/threonine protein kinase complex. It regulates important processes such as cell cycle, apoptosis, and transcription, and affects viral infection. During mitosis, CSNK2A2 maintains CDK1 activity and induces cell cycle arrest. In addition, CSNK2A2 phosphorylates p53/TP53 and negatively regulates apoptosis. It widely affects cell signaling, phosphorylated caspases, the apoptotic factor NOL3, and RNA polymerase, among others. CSNK2A2 also regulates Wnt signaling and acts as a kinase for extracellular proteins. CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) is the recombinant human-derived CK2 alpha/CSNK2A2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76263

	CSNK2A1 Protein, Human (Active, sf9, GST) 1 Publications Verification Casein Kinase II subunit alpha; CK II alpha; CSNK2A1; CK2A1	Human	Sf9 insect cells
	CK2α/CSNK2A1 protein can phosphorylate serine or threonine. It is involved in the regulation of cell cycle, apoptosis, transcription and viral infection, and has protective effects on the spindle assembly checkpoint and p53/TP53-mediated apoptosis. CK2α/CSNK2A1 can also participate in signal transduction by phosphorylating various factors, affecting circadian clock function and virus life cycle. CSNK2A1 Protein, Human (sf9, GST) is the recombinant human-derived CK2 alpha/CSNK2A1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P702741

	CSNK2A1 Protein, Human (His) CSNK2A1; casein Kinase 2 alpha 1; CKII; CKa1; CKa2; CK2A1; OCNDS	Human	E. coli
	The CSNK2A2 protein is a constitutively active kinase that phosphorylates substrates and controls the cell cycle, apoptosis, and transcription. CSNK2A1 Protein, Human (His) is the recombinant human-derived CSNK2A1, expressed by E. coli, with His labeled tag. The total length of CSNK2A1 Protein, Human (His) is 391 a.a..

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Cat. No.	Product Name	Chemical Structure

HY-14393S

Emodin-d4
Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IHC-F (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80586

	Casein Kinase 2 beta Antibody (YA563) CSNK2B; CK2N; G5A; Casein Kinase II subunit beta; CK II beta; Phosvitin; Protein G5a	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Casein Kinase 2 beta Antibody (YA563) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 2 beta.

HY-P80586A

	Casein Kinase 2 beta Antibody (YA563)(PBS only) CSNK2B; CK2N; G5A; Casein Kinase II subunit beta; CK II beta; Phosvitin; Protein G5a	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Casein Kinase 2 beta Antibody (YA563) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 2 beta.