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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
Protein Kinase CK2
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "Protein Kinase CK2" in MCE Product Catalog:
42
42 Publications Verification
Synonyms: Frangula emodin
Category:
Polygonaceae Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Cancer
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2 Cited Publications
Cat. No.: HY-P3815
CAS No.: 132176-35-3
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2
2 Cited Publications
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy .
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1 Cited Publications
Cat. No.: HY-P76263
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase 2 Alpha 1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase II Subunit Alpha; Casein Kinase II Alpha 1 Subunit; CKa1; CK2 Catalytic Subunit Alpha; CKa2; Protein Kinase CK2
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Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections .
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BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)
Cat. No.: HY-P4056A
Synonyms: P15-Tat acetate
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Cat. No.: HY-124321
CAS No.: 53734-79-5
Metralindole hydrochloride is an inhibitor of human cyclin-dependent kinase CDK2 and human protein kinase CK2 holoenzyme. Metralindole hydrochloride shows good potential as a non-small cell lung cancer inhibitor .
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CK156, a chemical probe, is a highly selective death-associated protein kinase (DAPK) inhibitor with IC50s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases .
Cat. No.: HY-P4056
CAS No.: 1072877-99-6
Synonyms: P15-Tat
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Cat. No.: HY-E70625
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Casein Kinase 2 (CK2) is a serine/threonine protein kinase that is highly conserved among eukaryotes and has roles in many different cellular processes, such as cell survival, cell cycle regulation, cell polarity, stress responses, transcription and translation .
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CK2-IN-4 (compound 5) is a protein kinase (CK2) inhibitor (IC50=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis .
Cat. No.: HY-174350
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CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases .
Cat. No.: HY-148763
CAS No.: 1309835-18-4
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CK2-IN-6 is a potent protein kinase CK2 inhibitor that can be used in the study of cancer as well as other kinase-related conditions, including inflammation, pain and certain immune diseases .
Cat. No.: HY-14393S
CAS No.: 132796-52-2
Synonyms: Frangula emodin-d4
Cat. No.: HY-184824
CAS No.: 1417638-06-2
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CK2-IN-18 is a protein kinase CK2 inhibitor with an IC50 of > 30 μM against protein kinase CK2. CK2-IN-18 can be used in studies related to CK2-mediated signaling pathways, such as various cancers including lung cancer and breast cancer .
Cat. No.: HY-118403
CAS No.: 300675-28-9
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CK2-IN-12 (Compound 39) is an inhibitor for protein kinase CK2 with an IC50 of 0.8 μM .
Cat. No.: HY-169629
CAS No.: 474263-21-3
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CK2 inhibitor 4 (compound 5b) is a protein kinase CK2 inhibitor with IC50 of 3.8 μM. CK2 inhibitor 4 can be used in tumor research .
Cat. No.: HY-117332
CAS No.: 391670-48-7
Synonyms: CGP-029482
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IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
