81-61-8
Chemical Structure
Quinalizarin
- CAS No.: 81-61-8
- Formula:C14H8O6
- Molecular Weight:272.21
IUPAC Name: 1,2,5,8-tetrahydroxyanthracene-9,10-dione
InChIKey: VBHKTXLEJZIDJF-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(O)=CC=C2O)C(C3=CC=C(O)C(O)=C13)=O
Biological Activity: Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Quinalizarin | 97.23% | Quinalizarin is a protein kinase CK2 inhibitor with a Ki of 0.052 μM. Quinalizarin exhibits antifungal and anticancer activities. Quinalizarin induces ROS production, apoptotic signaling, mitochondrial pathway activation, cell cycle arrest, and cytotoxicity in cancer cells. Quinalizarin inhibits hyphal growth, biofilm formation, and mature biofilm integrity of Candida albicans. Quinalizarin can be used in research related to cancer and fungal infections. | ||||||||||||||||||||
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- [1]. Meng LQ, et al. Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. Med Sci Monit. 2018;24:3710-3719. Published 2018 Jun 3. [Content Brief]
- [2]. Cozza G, et al. Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J. 2009;421(3):387-395. Published 2009 Jul 15. [Content Brief]
- [3]. Meng LQ, et al. Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways. Mol Med Rep. 2018;17(2):2626-2634. [Content Brief]
- [4]. Janeczko M, et al. Quinalizarin as a potential antifungal drug for the treatment of Candida albicans fungal infection in cancer patients. Microbiol Spectr. 2024 Mar 5;12(3):e0365223. [Content Brief]
Keywords
