Islandicin
Islandicin is an anthraquinone compound isolated from almonds. It has antibacterial activity.
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- CAS No.: 476-56-2
- Formule: C15H10O5
- Masse moléculaire:270.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-1 | IC50 |
>100 μM
Compound: 8
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Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| Calu-3 | IC50 |
>50 μM
Compound: 6
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Cytotoxicity against human Calu3 cells after 96 hrs by Cell Titer Glo assay
Cytotoxicity against human Calu3 cells after 96 hrs by Cell Titer Glo assay
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[PMID: 23057874] |
| HeLa | IC50 |
>100 μM
Compound: 8
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Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| K562 | IC50 |
>100 μM
Compound: 8
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Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| Raji | IC50 |
>100 μM
Compound: 8
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Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| Vero | IC50 |
>100 μM
Compound: 8
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Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
| WISH | IC50 |
>100 μM
Compound: 8
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Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
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[PMID: 11374975] |
Chemical Information
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CAS No. 476-56-2
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Masse moléculaire 270.24
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Formule C15H10O5
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SMILES
O=C1C2=C(C(C3=C(C=C(C)C(O)=C13)O)=O)C(O)=CC=C2
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Structure Classification
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Initial Source
Penicillium islandicum Sopp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Pureté et documentation
Références
[1]. Lin LC, et al. Cytotoxic principles from Ventilago leiocarpa. J Nat Prod. 2001 May;64(5):674-6. doi: 10.1021/np000569d. PMID: 11374975. [Content Brief]
[2]. Stark AA, et al. Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum. J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):313-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Islandicin Related Classifications
HY-N15488 Related Classifications
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