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R-L3 (Standard)

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14

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108591R
    L-364,373 (Standard)

    R-L3 (Standard)

    		 Reference Standards Potassium Channel Cardiovascular Disease
    L-364,373 (Standard) is the analytical standard of L-364,373 (HY-108591). This product is intended for research and analytical applications. L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .
    L-364,373 (Standard)
  • HY-13326R
    ASP3026 (Standard)

    		Anaplastic lymphoma kinase (ALK) Apoptosis ROS Kinase Caspase PARP IGF-1R STAT Akt JNK Cancer
    ASP3026 (Standard) is the analytical standard of ASP3026. This product is intended for research and analytical applications. ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC50 value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research .
    ASP3026 (Standard)
  • HY-45119R
    Corey lactone benzoate impurity 1 (Standard)

    		Reference Standards
    (3aR,4R,5R,6aS)-2-Oxo-4-((R,E)-3-oxo-4-(m-tolyl)pent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate (Standard) is the analytical standard of (3aR,4R,5R,6aS)-2-Oxo-4-((R,E)-3-oxo-4-(m-tolyl)pent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate. This product is intended for research and analytical applications.
    Corey lactone benzoate impurity 1 (Standard)
  • HY-77964R
    Ticagrelor impurity 11 (Standard)

    		Reference Standards
    (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid (Standard) is the analytical standard of (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid. This product is intended for research and analytical applications.
    Ticagrelor impurity 11 (Standard)
  • HY-Z4409R
    Sitagliptin impurity 6 (Standard)

    		Reference Standards
    (R)-Ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (Sitagliptin Impuruity) (Standard) is the analytical standard of (R)-Ethyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (Sitagliptin Impuruity). This product is intended for research and analytical applications.
    Sitagliptin impurity 6 (Standard)
  • HY-W714686R
    (R)-4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol (Standard)

    		Reference Standards
    (R)-4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol (Standard) is the analytical standard of (R)-4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol. This product is intended for research and analytical applications.
    (R)-4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol (Standard)
  • HY-100218CR
    (1R,3R)-RSL3 (Standard)

    		Drug Isomer Ferroptosis Reference Standards Cancer
    (1R,3R)-RSL3 (Standard) is the analytical standard of (1R,3R)-RSL3 (HY-100218C). This product is intended for research and analytical applications. (1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    (1R,3R)-RSL3 (Standard)
  • HY-128720R
    Diethyl oxalpropionate (Standard)

    		Endogenous Metabolite Reference Standards Metabolic Disease
    Diethyl oxalpropionate (Standard) is the analytical standard of Diethyl oxalpropionate. This product is intended for research and analytical applications. Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .
    Diethyl oxalpropionate (Standard)
  • HY-78628R
    Grazoprevir impurity 1 (Standard)

    		Reference Standards
    1-(tert-Butyl) 2-methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate (Standard) is the analytical standard of 1-(tert-Butyl) 2-methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate. This product is intended for research and analytical applications.
    Grazoprevir impurity 1 (Standard)
  • HY-103558R
    LY379268 (Standard)

    		Reference Standards mGluR Neurological Disease
    LY379268 (Standard) is the analytical standard of LY379268 (HY-103558). This product is intended for research and analytical applications. LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .
    LY379268 (Standard)
  • HY-I1122R
    (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (Standard)

    		Reference Standards
    (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (Standard) is the analytical standard of (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (HY-I1122). This product is intended for research and analytical applications.
    (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (Standard)
  • HY-100218AR
    RSL3 (Standard)

    (1S,3R)-RSL3 (Standard)

    		 p62 Glutathione Peroxidase Reference Standards Ferroptosis Reactive Oxygen Species (ROS) Cancer
    RSL3 (Standard) is the analytical standard of RSL3 (HY-100218A). This product is intended for research and analytical applications. RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
    RSL3 (Standard)
  • HY-103130R
    EMD386088 (Standard)

    		Reference Standards 5-HT Receptor Neurological Disease
    EMD386088 (Standard) is the analytical standard of EMD386088 (HY-103130). This product is intended for research and analytical applications. EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM). EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia .
    EMD386088 (Standard)
  • HY-10624R
    THIQ (Standard)

    		Reference Standards Melanocortin Receptor Metabolic Disease
    THIQ (Standard) is the analytical standard of THIQ (HY-10624). This product is intended for research and analytical applications. THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .
    THIQ (Standard)

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