1 Result for "

REGN-2878

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "REGN-2878" in MCE Product Catalog:

REGN2878
REGN2878
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Cat. No.: HY-P992449
Synonyms: PRLR ADC antibody

Target:  

ADC Antibodies

Research Areas:  

Cancer

REGN2878 (PRLR ADC antibody) is a monoclonal antibody targeting the prolactin receptor (PRLR) and can block prolactin‑mediated activation of PRLR. REGN2878 exhibits an equilibrium dissociation constant (KD) of 1.05 nM and an IC50 of 0.344 nM for human PRLR. REGN2878 can be rapidly internalized and degraded in lysosomes by PRLR‑positive tumor cells, showing antigen‑specific binding and targeted enrichment properties. REGN2878 derivatives can be used as an immunoPET agent for antigen‑specific imaging of PRLR‑related tumors, and can also serve as a component of ADCs to exert anti‑tumor activity in breast cancer xenograft models. REGN2878 can be used in the research of breast cancer and prostate cancer. Isotype Comparison HY-P99001 .
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